Browsing by Author "González Lira, Víctor"

Now showing items 1-4 of 4

    • Copper modifies liver microsomal UDP-glucuronyltransferase activity through different and opposite mechanisms 
      Letelier Muñoz, María Eugenia; Lagos, Fernando; Faúndez, Mario; Miranda, Dante; Montoya, Margarita; Aracena Parks, Paula; González Lira, Víctor (ELSEVIER IRELAND LTD, 2007-04)
      Treatment of hepatic microsomes with Fe3+/ascorbate activates UDP-glucuronyltransferase (UGT), a phenomenon totally prevented and reversed by reducing agents. At #2;M concentrations, iron and copper ions catalyze the ...
    • DPPH and oxygen free radicals as pro-oxidant of biomolecules 
      Letelier Muñoz, María Eugenia; Molina Berríos, Alfredo Enrique; Cortés Troncoso, Juan; Jara Sandoval, José; Holst, Marianne; Palma, Karina; Montoya, Margarita; Miranda, Dante; González Lira, Víctor (PERGAMON-ELSEVIER SCIENCE LTD, 2008-03)
      Numerous investigations exist about the alterations that oxygen free radicals can provoke on biomolecules; these modifications can be prevented and/or reversed by different antioxidants agents. On the other hand, ...
    • Inhibition of cytosolic glutathione S-transferase activity from rat liver by copper 
      Letelier Muñoz, María Eugenia; Martínez, M.; González Lira, Víctor; Faúndez, Mario; Aracena Parks, Paula (ELSEVIER, 2006-12-01)
      H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...
    • Nitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, ... 
      Letelier Muñoz, María Eugenia; Entrala Alrruiz, Paz Andrea; López Alarcón, Camilo; González Lira, Víctor; Molina Berríos, Alfredo Enrique; Cortés Troncoso, Juan; Jara Sandoval, José; Santander, P.; Núñez Vergara, Luis (PERGAMON-ELSEVIER SCIENCE, 2007-12)
      1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...