Browsing by Author "Parra Ortíz, María Valentina"

Now showing items 1-10 of 10

    • Autofagia del cardiomiocito: ¿Un nuevo mecanismo de adaptación al estrés o de muerte celular? 
      Aránguiz Urroz, Pablo Daniel; Contreras Ferrat, Ariel Eduardo; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo Hernán; Marambio Morales, Paola Angélica; Toro, Bárbara; Sanhueza Muñoz, Carlos Joaquín; Pennanen Saavedra, Christian; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      Históricamente, la apoptosis y la necrosis han sido consideradas como las dos formas fundamentales de muerte celular. Sin embargo, evidencias recientes sugieren que la muerte celular programada no está confinada sólo a ...
    • Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis 
      Parra Ortíz, María Valentina; Eisner, Verónica; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Moraga, Francisco; García, Alejandra; Haertel, Steffen; Jaimovich Pérez, Enrique; Zorzano, Antonio; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2008-01-15)
      Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
    • Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy 
      Westermeier, Francisco; Navarro Márquez, Mario F.; López Crisosto, Camila; Bravo Sagua, Roberto; Quiroga Lagos, Clara; Bustamante, Mario; Verdejo, Hugo E.; Zalaquett Sepúlveda, Ricardo; Ibacache, Mauricio; Parra Ortíz, María Valentina; Castro, Pablo F.; Rothermel, Beverly A.; Hill, Joseph A.; Lavandero González, Sergio (Elsevier, 2015)
      Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart.Myocardial energy metabolism ...
    • IGF-1: Un factor de crecimiento con acciones cardiovasculares pleiotrópicas. 
      Contreras Ferrat, Ariel Eduardo; Aránguiz Urroz, Pablo Daniel; Díaz Elizondo, Jessica; Chiong Lay, Mario; Muñoz, Juan Pablo; Parra Ortíz, María Valentina; Ibarra, Cristián; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo; Eisner, Verónica; Salas, Daniela; Rodríguez Villarroel, Andrea Elizabeth; Carrasco Alarcón, Loreto del Pilar; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases ... 
      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo E.; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, Gyorgy; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD., 2011-07-15)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The ...
    • An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose ... 
      Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Bravo, R.; Parra Ortíz, María Valentina; Vásquez, C.; Ibarra, Cristián; Mears, David; Chiong Lay, Mario; Jaimovich Pérez, Enrique; Klip, Amira; Lavandero González, Sergio (ENDOCRINE SOC, 2010-10)
      Intracellular calcium levels ([Ca2+](i)) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca2+](i) in cultured ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Del Campo Sfeir, Andrea Estefanía; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Permanganometría de hierro y titanio utilizando análisis por inyección en flujo 
      Richter Duk, Pablo; Toral Ponce, María; Parra Ortíz, María Valentina; Fuentes, Sandra; Araya, Eyleen (Sociedad Chilena de Química, 1995)
      Se desarrolla un método automático de análisis por inyección en flujo (FIA) para la determinación simultánea de hierro y titanio en mezclas. El método se basa en el diseño de una configuración FIA que incluye la reducción ...
    • Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species 
      Rojas Rivera, Andrés; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Salas, Daniela; Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Chiong Lay, Mario; Olea Azar, Claudio; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2009-11-03)
      We investigated the role of Ca2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic ...
    • The complex interplay between mitochondrial dynamics and cardiac metabolism 
      Parra Ortíz, María Valentina; Verdejo, Hugo; Campo Sfeir, Andrea Estefanía del; Pennanen Saavedra, Christian; Kuzmicic, Jovan; Iglewski, Myriam; Hill, Joseph A.; Rothermel, B. A.; Lavandero González, Sergio (SPRINGER/PLENUM PUBLISHERS, 2011-02)
      Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of ...