Browsing by Author "Pessoa, D."

Now showing items 1-11 of 11

    • 1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 ... 
      Vásquez, David; Lagos González, Carlos F.; Mella Raipán, Jaime A.; González, Luis; Ebensperger González, Roberto; Alvarez Figueroa, M. Javiera; Sáez, Edmundo; Pessoa Mahana, Hernán; Araya Secchi, Raúl; González Wong, Angel; Pérez-Acle, Tomás; Pessoa, D. (SOC CHILENA QUIMICA, 2007-12)
      A novel approach to the development of anew class of HIV-1 RT inhibitors is reported. The 1-benzoyl-2-aryl-1H-benzimidazole series was designed as a combination of two previously reported active scaffolds, the benzimidazole ...
    • A Synthetic Overview of New Molecules with 5-HT1A Binding Affinities 
      Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Pessoa, D. (Bentham Science Publishers, 2003)
      The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally related to arylpiperazine, ...
    • A facile approach for new dibenzo [b,f][1,5] diazocinones 
      Pessoa Mahana, Hernán; Martínez Aranguiz, Gracia Karen; Araya Maturana, Ramiro; Pessoa, D. (TAYLOR & FRANCIS INC, 2005)
      The synthesis of new eight-membered cycle dibenzo[b,f][1,5]-diazocine-6(5H)-one derivatives 11, 12 was developed. The key step in this synthesis was the intramolecular cyclization of the amino aldehyde precursors 9,10 ...
    • Microwave-assisted synthesis and regioisomeric structural elucidation of novel benzimidazo[1,2d][1,4]benz ... 
      Pessoa, D.; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Canales Pacheco, Jorge; Pessoa Mahana, Hernán (ARKAT USA INC, 2009)
      The synthesis of 5H-benzimidazo [1,2-d] [1,4] benzodiazepin -6(7H)-ones 3a-e from readily available 2-(2-aminophenyl)-1H-benzo[d]imidazole derivatives 2a-e and 2-bromoacetyl bromide under microwave conditions is described. ...
    • Solvent-free microwave-promoted Michael addition of aza-nucleophiles to benzo[b] thiophen-2-yl-2-propenone 
      Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa, D.; Araya Maturana, Ramiro; Ron Higuera, Nadia Betsabé; Saitz Barría, Claudio (ARKAT USA INC, 2009)
      A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b] thiophen-2 ...
    • Solvent-free synthesis of 6-arylbenzimidazo[1,2-c]quinazolines under microwave irradiation 
      Pessoa Mahana, Hernán; Pessoa, D.; Salazar González, Ricardo Andrés; Valderrama Guerrero, Jaime Adolfo; Sáez, Edmundo; Araya Maturana, Ramiro (GEORG THIEME VERLAG KG, 2004-02-18)
      The syntheses of 2-(2-nitrophenyl)-1-benzoyl-1H-benzimidazole derivatives 5-9 and their reduction to the corresponding 2-benzimidazoylbenzamides 10-13 are described. Compounds 10-13 were cleanly and efficiently converted ...
    • Studies on quinones. Part 36. Synthesis and trypanocidal activity of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones 
      Pessoa, D.; Valderrama Guerrero, Jaime Adolfo; Olmos, María G.; Espinoza, Omar; Pessoa Mahana, Hernán; Rojas de Arias, Antonieta; Nakayama, Héctor; Torres, Susana; Miret, Jorge (FREUND PUBLISHING HOUSE LTD, 2002)
      A series of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones (11-15), prepared from the corresponding acid 5, were tested in vitro against trypomastigote form of Trypanosome cruzi. The influence of the lypophilia and oxidant ...
    • Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs 
      Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)
      A novel series of 2-benzothienyl carbonyl arylpiperazines (6a-f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene ...
    • Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action 
      Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Araya Maturana, Ramiro; Kosche Cárcamo, Johann Albert; Pessoa, D. (MARCEL DEKKER INC, 2004-07)
      We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual ...
    • Synthesis of conformationally restricted N-{4-[4-(4,7-Dimethoxy-Benzo[b]Thiophene-2-Carbonyl)-1-Piperazin ... 
      Pessoa Mahana, Hernán; González Lira, Christian Guillermo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (SOC CHILENA QUIMICA, 2009-06)
      New benzothiophene arylpiperazine derivatives 7 (a-1) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminophenyl)-4-[(4 ...
    • A synthethic overview of new molecules with 5-HT 1A binding affinities 
      Pessoa Mahana, Hernán; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (Bentham Science Publishers, Ltd, 2003)
      The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally telated to arylpiperazine, ...