Recent Submissions

  • Chitosan-based delivery of avian reovirus fusogenic protein p10 gene: in vitro and in vivo studies towards a new vaccine against melanoma 

    Robles Planells, Claudia; Barrera Ávalos, Carlos; Rojo, Leonel E.; Spencer, Eugenio; Cortez San Martín, Eugenio; Matiacevich, Silvia; Pavez, Jorge; Milla, Luis A.; Navarro, Franco D.; Martínez, Brandon A; Bravo, Francisco J.; Mella, Andrea; Huidobro Toro, Juan Pablo; Fernández, Ricardo; Escobar Álvarez, Alejandro; Acuña Castillo, Claudio (Hindawi, 2020)
    Reovirus is known to have an anticancer effect in both the preclinical and clinical assays. Current evidence suggests that the reovirus-mediated impact on tumor growth depends on the activation of specific antitumor immune ...
  • Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance 

    Cafferatta Chea, Emilio; Castro Saavedra, Sebastián; Fuentes Barros, Gonzalo; Melgar Rodríguez, Samanta; Rivera Rodríguez, Felipe; Carvajal Pavez, Paola; Hernández Ríos, Emma; Cortés, Bastián; Cortez, Cristian; Cassels Niven, Bruce; Vernal Astudillo, Rolando (Wiley, 2020)
    Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ...
  • Bacterial synthesis of ternary CdSAg quantum dots through cation exchange: tuning the composition and properties of biological nanoparticles for bioimaging and photovoltaic applications 

    Órdenes Aenishanslins, Nicolás; Anziani Ostuni, Giovanni; Monrás, Juan Pablo; Tello, Alejandra; Bravo Rodríguez, Denisse; Toro Ascuy, Daniela; Soto Rifo, Ricardo; Prasad, Paras N.; Pérez Donoso, José (MDPI, 2020)
    In this study, we introduce a biological method for the production of ternary Quantum Dots (QDs): complex nanostructures with tunable optical and structural properties that utilizes post-synthesis modifications through ...
  • Acid bone lysates reduce bone regeneration in rat calvaria defects 

    Strauss Avendaño, Franz Josef; Kuchler, Ulrike; Kobatake, Reiko; Heimel, Patrick; Tangl, Stefan; Gruber, Reinhard (Wiley, 2020)
    Acid bone lysates (ABLs) represent the growth factors and other molecules released during autologous graft resorption. However, the impact of these bone-derived growth factors on the healing of bone defects has not yet ...
  • Wnt/beta-Catenin Signaling in Oral Carcinogenesis 

    Reyes Rojas, Montserrat; Flores Lillo, Tania; Betancur, Diego; Peña Oyarzún, Daniel; Torres Gómez, Vicente (MDPI, 2020)
    Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair and defective cell death. At the ...
  • PKD2/polycystin-2 induces autophagy by forming a complex with BECN1 

    Peña Oyarzún, Daniel; Rodríguez Peña, Marcelo; Burgos Bravo, Francesca; Vergara, Ángelo; Kretschmar Montecinos, Catalina; Sotomayor Flores, Cristián; Ramírez Sarmiento, César A.; De Smedt, Humbert; Reyes Rojas, Montserrat; Pérez, William; Torres Gómez, Vicente; Morselli, Eugenia; Altamirano, Francisco; Wilson, Christian; Hill, Joseph A.; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Taylor & Francis, 2020)
    Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a ...
  • Inflammatory biomarkers in dentinal fluid as an approach to molecular diagnostics in pulpitis 

    Brizuela, C.; Meza, G.; Mercadé, M.; Inostroza, C.; Chaparro, A.; Bravo, I.; Briceño, C.; Hernández, M.; Giner, L.; Ramírez, V. (Wiley, 2020)
    Aim To explore a set of inflammatory biomarkers obtained from dentinal fluid (DF) from patients with symptomatic irreversible pulpitis (IP), reversible pulpitis (RP) and normal pulp (NP). Methodology A cross-sectional ...
  • Association between IRF6 variants and nonsyndromic cleft lip with or without cleft palate in Chile 

    Suazo Sanhueza, José; Recabarren, Andrea S.; Marín, Nicolás R.; Blanco Castillo, Rafael (Springer, 2020)
    The aim of this study was to assess the association betweenIRF6single nucleotide polymorphisms and nonsyndromic cleft lip, with or without cleft palate (NSCL/P), in a Chilean population, based on a case-control sample and ...
  • TGFβ activity released from platelet-rich fibrin adsorbs to titanium surface and collagen membranes 

    Di Summa, Francesca; Kargarpour, Zahra; Nasirzade, Jila; Stähli, Alexandra; Mitulović, Goran; Panić Janković, Tanja; Koller, Veronika; Kaltenbach, Cosima; Müller, Heinz; Panahipour, Layla; Gruber, Reinhard; Strauss, Franz Josef (Nature, 2020)
    Platelet-rich fibrin (PRF) contains a broad spectrum of bioactive molecules that can trigger several cellular responses. However, these molecules along with their upstream responses remain mostly uninvestigated. By means ...
  • miRNA-21 deficiency impairs alveolar socket healing in mice 

    Strauss Avendaño, Franz; Stahli, Alexandra; Kobatake, Reiko; Tangl, Stefan; Heimel, Patrick; Alccayhuaman, Karol Ali Apaza; Schosserer, Markus; Hackl, Matthias; Grillari, Johannes; Gruber, Reinhard (Wiley, 2020)
    Objectives MicroRNAs (miRNAs) are small noncoding RNAs demonstrated as critical post-transcriptional modulators in dental tissues and bone regeneration, particularly miR-21-5p. However, the role of miR-21-5p in the healing ...
  • Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease 

    Muñoz, Pablo; Ardiles, Álvaro O.; Pérez Espinosa, Boris; Núñez Espinosa, Cristian; Paula Lima, Andrea; González Billault, Christian; Espinosa Parrilla, Yolanda (Elsevier, 2020)
    Aging is a natural process that includes several changes that gradually make organisms degenerate and die. Harman's theory proposes that aging is a consequence of the progressive accumulation of oxidative modifications ...
  • Mediación en el sistema público de salud: oportunidades para mejorar 

    Lagos Tissie, Denisse; Bravo R., Lidia (Sociedad Médica Santiago, 2020)
    La mediación en el cuidado de la salud es un proceso no contencioso para resolver una disputa entre pacientes y proveedores de servicios de salud durante la atención médica Objetivo: Caracterizar el proceso de mediación ...
  • El gobierno de las poblaciones: Augusto Orrego Luco y la cuestión social en Chile 

    Leyton Robinson, César (Consejo Superior Investigaciones Cientificas-CSIC, 2020)
    Based on two essential texts by Chilean doctor Augusto Orrego Luco - La cuestion social (The Social Question, 1897) and his Discurso de toma de posesion de su cargo de presidente de la Sociedad Medica (Speech on taking up ...
  • Untitled 

    Salamanca, Carlos; González Hormazábal, Patricio; Recabarren, Andrea S.; Recabarren, Pamela A.; Pantoja, Roberto; Leiva Villagra, Noemí; Pardo Vargas, Rosa; Suazo Sanhueza, José Lorenzo (2020)
    Background TheS-adenosyl-methionine (SAM) availability is crucial for DNA methylation, an epigenetic mechanism involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression. The aim of this study was ...
  • Fasciola hepatica coinfection modifies the morphological and immunological features of Echinococcus granulosus cysts in cattle 

    Hidalgo, Christian; Stoore, Caroll; Hernández, Marcela; Paredes, Rodolfo (BMC, 2020)
    Polyparasitism occurs when animals harbour multiple parasites concomitantly. It is a common occurrence but is generally understudied in wild and domestic animals. Fasciola hepatica and Echinococcus granulosus, which are ...
  • Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes 

    Vicencio, Emiliano; Cordero, Esteban M.; Cortés, Bastián I.; Palominos, Sebastián; Parra, Pedro; Mella, Tania; Henrríquez, Constanza; Salazar, Nelda; Monasterio Ocares, Gustavo; Cafferata, Emilio A.; Murgas, Paola; Vernal Astudillo, Rolando; Cortez, Cristian (MDPI, 2020)
    The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ...
  • Morphological consequences of artificial cranial deformation: Modularity and integration 

    Puschel, Thomas A.; Friess, Martin; Manríquez Soto, Germán (Public Library Science, 2020)
    The cranium is an anatomically complex structure. One source of its complexity is due to its modular organization. Cranial modules are distinct and partially independent units that interact substantially during ontogeny ...
  • Establishment and Stability of the Murine Oral Microbiome 

    Abusleme Ramos, Loreto Andrea; O'Gorman, H.; Dutzan Muñoz, Nicolás; Greenwell-Wild, T.; Moutsopoulos, N. M. (SAGE, 2020)
    Commensal microbiomes exert critical functions at barrier sites. In particular, establishment of the commensal microbiome after birth dictates immune functionality and tissue homeostasis at mucosal surfaces. To investigate ...
  • Efficacy of growth factors for the treatment of peri-implant diseases: a systematic review and meta-analysis 

    Khouly, Ismael; Pardinas López, Simón; Ruff, Ryan Richard; Strauss Avendaño, Franz Josef (Springer, 2020)
    Objectives The aim of this study was to conduct a systematic review and meta-analysis on the efficacy of growth factors (GF) on clinical outcomes after treatment (surgical/non-surgical) of peri-implant diseases (peri-implant ...
  • Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis 

    Veloso Matta, Pablo; Fernández, Alejandra; Terraza, Claudia; Álvarez Rivas, Carla; Vernal Astudillo, Rolando; Escobar Álvarez, Alejandro; Hernández Ríos, Emma (Springer, 2020)
    Objectives To explore the macrophage profiles in symptomatic and asymptomatic forms of AP through phenotypic and functional analyses. Material and methods Cross-sectional study. Apical tissue/lesion samples were collected ...

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