Browsing by Author "201-0372327"
Now showing items 1-15 of 15
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Suwalsky, Mario; Duguet, José; Speisky Cosoy, Hernán (Springer, 2017)The antioxidant and antihemolytic properties contained in the leaves of Buddleja globosa (B. globosa), also known as "Matico," were determined. Aqueous extracts of leaves were assayed in human erythrocytes and molecular ...
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O'Brien, Peter; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (ELSEVIER, 2006-01-05)The increasing recognition of the participation of free radical-mediated oxidative events in the initiation and/or progression of cardiovascular, tumoural, inflammatory and neurodegenerative disorders, has given rise to ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-07-01)Cu2+ ions and GSH molecules interact to swiftly form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing Cu(I)– ...
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Aliaga, Margarita E.; Carrasco Pozo, Catalina; López Alarcón, Camilo; Speisky Cosoy, Hernán (Springer, 2010)Cu2? ions and reduced glutathione (GSH) swiftly interact to form the physiologically occurring Cu(I)–[GSH]2 complex. Prompted by the recently reported ability of this complex to generate superoxide radicals from molecular ...
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Carrasco Pozo, Catalina; Mizgier, María Luisa; Speisky Cosoy, Hernán; Gotteland, Martín (Elsevier, 2012)The beneficial effects of dietary polyphenols on health are due not only to their antioxidant properties but also to their antibacterial, anti-inflammatory and/or anti-tumoral activities. It has recently been proposed that ...
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Carrasco Pozo, Catalina; Aliaga, Margarita E.; Olea Azar, Claudio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER, 2008-11-15)The present study investigated the redox-consequences of the interaction between various endogenous thiols (RSH)-glutathione, cysteine, homocysteine, c-glutamyl-cysteine, and cysteinyl-glycine-and Cu2+ ions, in terms of ...
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Rincón Cervera, Miguel Ángel; Galleguillos Fernández, Raúl; González Barriga, Barriga; Valenzuela Báez, Rodrigo; Speisky Cosoy, Hernán; Fuentes, Jocelyn; Valenzuela, Alfonso (Wiley, 2020)
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Carrasco Pozo, Catalina; Álvarez Lueje, Alejandro; Olea Azar, Claudio; López Alarcón, Camilo; Speisky Cosoy, Hernán (SOC EXPERIMENTAL BIOLOGY MEDICINE, 2006-10)Homocysteine (Hcys) has been implicated in various oxidative stress–related disorders. The presence of a thiol on its structure allows Hcys to exert a double-edge redox action. Depending on whether Cu2þions occur ...
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International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their ... Bridi, Raquel; Montenegro, Gloria; Núñez Quijada, Gabriel; Giordano, Ady; Morán Romero, María Fernanda; Jara Pezoa, Isaac; Speisky Cosoy, Hernán; Atala, Elías; López Alarcón, Camilo (Institute of Food Technologists, 2015)Propolis has been proposed as a polyphenolic-rich natural product potentially able to be used for human consumption or even for medicinal proposes. To guarantee a minimum phenolic and flavonoid content and as consequence ...
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Fuentes, Jocelyn; Arias Santé, M. Fernanda; Atala Riffo, Elías; Pastene, Edgar; Kogan Bocian, Marcelo; Speisky Cosoy, Hernán (Elsevier, 2020)The occurrence of the quercetin oxidation metabolite 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (BZF), whose antioxidant potency is notably higher than the antioxidant potency of quercetin, was investigated ...
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Gotteland, Martín; Andrews, Mónica; Toledo Cumplido, Marcela; Muñoz, Loreto; Cáceres, Paola; Anziani, Alyerina; Wittig Rovira, Emma; Speisky Cosoy, Hernán; Salazar Rodríguez, Gabriela (ELSEVIER, 2008-05)Objective: Probiotics and cranberry have been shown to inhibit Helicobacter pylori in vitro owing to bacteriocin production and high levels of proanthocyanidins, iespectively. These effects have been confirmed in clinical ...
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Fuentes Lemus, E.; Dorta, E.; Escobar, E.; Aspee, Alexis; Pino, E.; Abasq, M. L.; Speisky Cosoy, Hernán; Silva, E.; Lissi, E.; Davies, M. J.; López Alarcón, Camilo (Royal Society of Chemistry, 2016)The oxidation of tryptophan (Trp) residues, mediated by peroxyl radicals (ROO.), follows a complex mechanism involving free radical intermediates, and short chain reactions. The reactivity of Trp towards ROO. should be ...
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Atala, Elías; Fuentes, Jocelyn; Wehrhahn, María José; Speisky Cosoy, Hernán (Elsevier, 2017)Oxidation of a phenolic group in quercetin is assumed to compromise its antioxidant properties. To address this assumption, the ROS-scavenging, Folin-Ciocalteau- and Fe-reducing capacities of quercetin and thirteen ...
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Fuentes, Jocelyn; Atala, Elías; Pastene, Edgar; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (American Chemical Society, 2017)Quercetin oxidation is generally believed to ultimately result in the loss of its antioxidant properties. To test this assertion, quercetin oxidation was induced, and after each of its major metabolites was identified and ...
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Aliaga, Margarita E.; López Alarcón, Camilo; Bridi, Raquel; Speisky Cosoy, Hernán (Elsevier, 2016)Binding of copper by reduced glutathione (GSH) is generally seen as a mechanism to lower, if not abolish, the otherwise high electrophilicity and redox activity of its free ions. In recent years, however, this concept has ...