Browsing by Author "Tobar, Nicolás"

Now showing items 1-6 of 6

    • Adipogenic effect of calcium sensing receptor activation 
      Villarroel, Pia; Reyes Jedlicki, Marcela; Fuentes, Cecilia; Segovia, María Pia; Tobar, Nicolás; Villalobos, Elisa; Martínez Winkler, Jorge; Hugo, Eric; Ben-Jonathan, Nira; Cifuentes, Mariana (Springer, 2013)
      We established that human adipose cells and the human adipose cell line LS14 express the calciumsensing receptor (CaSR) and that its activation induces inflammatory cytokine production. Also, its expression is enhanced ...
    • c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a ... 
      Cáceres, Mónica; Tobar, Nicolás; Guerrero, Javier; Smith, Patricio C.; Martínez, Jorge (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)
      In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells. These cells ...
    • Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and ... 
      Cifuentes, Mariana; Fuentes, Cecilia; Tobar, Nicolás; Acevedo, Ingrid; Villalobos, Elisa; Hugo, Eric; Ben-Jonathan, Nira; Reyes Jedlicki, Marcela (Elsevier, 2012)
      The proinflammatory status of adipose tissue has been linked to the metabolic and cardiovascular consequences of obesity. Human adipose cells express the calcium sensing receptor (CaSR), and its expression is elevated ...
    • NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration 
      Tobar, Nicolás; Guerrero, Javier; Smith, Patricio C.; Martínez, Jorge (NATURE PUBLISHING GROUP, 2010-09-28)
      BACKGROUND: The influence of the stromal microenvironment on the progression of epithelial cancers has been demonstrated. Unravelling the mechanisms by which stromal cells affect epithelial behaviour will contribute in ...
    • RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase ... 
      Tobar, Nicolás; Cáceres, Mónica; Santibáñez, Juan Francisco; Smith, Patricio C.; Martínez, Jorge (Elsevier Inc., 2008-08-18)
      modulate the migratory properties in MCF-7 and T47D human mammary cell lines. We also described that the NFjB pathway exerts a downstream control on the expression of the ROS-dependent cellular migratory potential. These ...
    • Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human ... 
      Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar Oliva, Paula; Dotor, Javier; Smith, Patricio C.; Martínez Winkler, Jorge (Springer Science+Business Media, 2011)
      In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic response. ...