Browsing by Subject "Insulin"

Now showing items 1-3 of 3

    • Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in ... 
      Buchanan, Victoria L.; Wang, Yujie; Blanco, Estela; Graff, Mariaelisa; Albala Brevis, Cecilia; Burrows Argote, Raquel; Santos, José L.; Ángel, Barbara; Lozoff, Betsy; Voruganti, Venkata Saroja; Guo, Xiuqing; Taylor, Kent D.; Chen, Yii-Der Ida; Yao, Jie; Tan, Jingyi; Downie, Carolina; Highland, Heather M.; Justice, Anne E.; Gahagan, Sheila; North, Kari E. (Wiley, 2020)
      Background The genetic underpinnings of glycemic traits have been understudied in adolescent and Hispanic/Latino (H/L) populations in comparison to adults and populations of European ancestry. Objective To identify genetic ...
    • Glucocorticoid receptor β overexpression has agonist-independent insulin-mimetic effects on HepG2 glucose ... 
      Sepúlveda Quiñenao, Claudia Patricia; Rodríguez Silva, José Manuel; Díaz Castro, Francisco; Campo, Andrea del; Bravo Sagua, Roberto Francisco; Troncoso Cotal, Rodrigo Hernán (MDPI, 2022)
      Glucocorticoids (GC) are steroids hormones that drive circulating glucose availability through gluconeogenesis in the liver. However, alternative splicing of the GR mRNA produces two isoforms, termed GR alpha and GR beta. ...
    • Mifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells 
      Bernal Sore, Izela; Navarro Márquez, Mario F.; Osorio Fuentealba, César; Díaz Castro, Francisco; Campo, Andrea del; Donoso Barraza, Camila; Porras Espinoza, Omar; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (Elsevier, 2018)
      Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic ...