Relationship between the electrophilicity of substituting agents and substrate selectivity in Friedel-Crafts reactions

Author	dc.contributor.author	Meneses, L.
Author	dc.contributor.author	Fuentealba Rosas, Patricio	es_CL
Author	dc.contributor.author	Contreras Ramos, Renato	es_CL
Admission date	dc.date.accessioned	2007-05-22T18:57:00Z
Available date	dc.date.available	2007-05-22T18:57:00Z
Publication date	dc.date.issued	2005-01-24
Cita de ítem	dc.identifier.citation	TETRAHEDRON 61 (4): 831-836 JAN 24 2005	en
Identifier	dc.identifier.issn	0040-4020
Identifier	dc.identifier.uri	https://repositorio.uchile.cl/handle/2250/118634
Abstract	dc.description.abstract	The global electrophilicity index evaluated at the ground state of benzylating and acylating agents shows a quantitative linear relationship with the experimental substrate selectivity index evaluated for a series of Friedel-Crafts reactions. The theoretical scale correctly accounts for the electrophilic activation/deactivation effects promoted by electron withdrawing and electron releasing substituents in these molecules. The predicted substrate selectivity values estimated from the knowledge of the electrophilicity index may become accurate to within 10% and less.	en
Lenguage	dc.language.iso	en	en
Publisher	dc.publisher	PERGAMON-ELSEVIER SCIENCE	en
Keywords	dc.subject	AROMATIC SUBSTITUTION	en
Título	dc.title	Relationship between the electrophilicity of substituting agents and substrate selectivity in Friedel-Crafts reactions	en
Document type	dc.type	Artículo de revista