Author | dc.contributor.author | Benson, Micah J. | es_CL |
Author | dc.contributor.author | Pino, Karina | es_CL |
Author | dc.contributor.author | Rosemblatt Silber, Mario César | es_CL |
Author | dc.contributor.author | Noelle, Randolph J. | es_CL |
Admission date | dc.date.accessioned | 2008-05-14T13:57:59Z | |
Available date | dc.date.available | 2008-05-14T13:57:59Z | |
Publication date | dc.date.issued | 2007 | es_CL |
Cita de ítem | dc.identifier.citation | JOURNAL OF EXPERIMENTAL MEDICINE Vol. 204 AUG 6 2007 8 1765-1774 | es_CL |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/118695 | |
General note | dc.description | Publicación ISI | es_CL |
Abstract | dc.description.abstract | We demonstrate that all-trans retinoic acid (RA) induces Ill adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to the lamina propria of the small intestine. Under conditions that favor the differentiation of A-Tregs (transforming growth factor-beta 1 and interleukin 2) in vitro, the inclusion of RA induces nearly all activated Cl T cells to express FoxP3 and greatly increases the accumulation of these cells. In the absence of RA, A-Treg differentiation is abruptly impaired by proficient antigen presenting cells or through direct co-stimulation. In the presence of RA, A-Treg generation occurs even in the presence of high levels of co-stimulation, with RA attenuating co-stimulation from interfering from Ill induction. The recognition that RA induces gut imprinting, together with our finding that it enhances A-Treg conversion, differentiation, and expansion, indicates that RA production in vivo may drive both the imprinting and A-Treg development in the face of overt inflammation. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Keywords | dc.subject | TRANSCRIPTION FACTOR FOXP3 | es_CL |
Area Temática | dc.subject.other | Immunology; Medicine, Research & Experimental | es_CL |
Título | dc.title | All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation | es_CL |
Document type | dc.type | Artículo de revista | |