Author | dc.contributor.author | Aguirre, Pabla | |
Author | dc.contributor.author | Mena, Natalia P. | es_CL |
Author | dc.contributor.author | Tapia, Victoria | es_CL |
Author | dc.contributor.author | Rojas, Alejandro | es_CL |
Author | dc.contributor.author | Arredondo Olguín, Miguel Armando | es_CL |
Author | dc.contributor.author | Núñez González, Marco | es_CL |
Admission date | dc.date.accessioned | 2008-11-26T17:11:38Z | |
Available date | dc.date.available | 2008-11-26T17:11:38Z | |
Publication date | dc.date.issued | 2006 | |
Cita de ítem | dc.identifier.citation | Biol Res 39: 103-104, 2006 | en |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/118739 | |
Abstract | dc.description.abstract | Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione
levels. In this work, in cortical neurons we characterized viability and changes in reduced and oxidized glutathione levels in response to a protocol of iron accumulation. We found that massive death occurred after
2 days in culture with 10 µM Fe. Surviving cells developed an adaptative response that included increased synthesis of GSH and the maintenance of a glutathione-based reduction potential. These results highlight the
fundamental role of glutathione homeostasis in the antioxidant response and provide novel insights into the adaptative mechanisms of neurons subjected to progressive iron loads. | en |
Patrocinador | dc.description.sponsorship | Financed by FONDECYT grant 1040448
and by Millennium Scientific Initiative
grant P99-031. | en |
Lenguage | dc.language.iso | en | en |
Keywords | dc.subject | Glutathione | en |
Título | dc.title | Antioxidant responses of cortex neurons to iron loading | en |
Document type | dc.type | Artículo de revista | |