| Author | dc.contributor.author | Molina Salinas, Gloria María | |
| Author | dc.contributor.author | Bórquez, Jorge | es_CL |
| Author | dc.contributor.author | Ardiles, Alejandro | es_CL |
| Author | dc.contributor.author | Said Fernández, Salvador | es_CL |
| Author | dc.contributor.author | Loyola, Luis Alberto | es_CL |
| Author | dc.contributor.author | San Martín Barrientos, Aurelio | es_CL |
| Author | dc.contributor.author | González Collado, Isidro | es_CL |
| Author | dc.contributor.author | Peña Rodríguez, Luis Manuel | es_CL |
| Admission date | dc.date.accessioned | 2010-07-21T20:22:28Z | |
| Available date | dc.date.available | 2010-07-21T20:22:28Z | |
| Publication date | dc.date.issued | 2010 | |
| Cita de ítem | dc.identifier.citation | Fitoterapia 81 (2010) 50–54 | en_US |
| Identifier | dc.identifier.other | doi:10.1016/j.fitote.2009.07.005 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119082 | |
| Abstract | dc.description.abstract | The antituberculosis activity of 14 natural azorellane and mulinane diterpenoids isolated from
Azorella compacta, Azorella madreporica, Mulinum crassifolium, and Laretia acaulis, together
with eight semisynthetic derivatives, was evaluated against two Mycobacterium tuberculosis
strains. The natural azorellanes azorellanol (3) and 17-acetoxy-13-α-hydroxyazorellane (6),
and the semisynthetic mulinanes 13-hydroxy-mulin-11-en-20-oic-acid methyl ester (13) and
mulinenic acid methyl ester (23), showed the strongest activity, with MIC values of 12.5 μg/mL
against both strains. The methylated derivatives 13-hydroxy-mulin-11-en-20-oic-acid methyl
ester (13), mulin-11,13-dien-20-oic acid methyl ester (15) and mulinenic acid methyl ester (23)
proved to be more active than the parent compounds. | en_US |
| Patrocinador | dc.description.sponsorship | GMMS wishes to thank Consejo Nacional de Ciencia y
Tecnología-México for a postdoctoral fellowship, and Programa
de Cooperación Internacional de la Coordinación de
Investigación en Salud-IMSS, for supporting a research stay at
Universidad de Antofagasta, Antofagasta, Chile. LAL wishes to
acknowledge FONDECYT-Chile support for this project (Grant
No. 1060339). The evaluation of antituberculosis activity in
this collaborative work was supported by Instituto Mexicano
del Seguro Social (Project 2008-1908-4). Research was performed
under the auspices of the EULADIV Alfa Project and
FOMIX-Yucatán Project No. 66262. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | ELSEVIER | en_US |
| Keywords | dc.subject | Azorellane | en_US |
| Título | dc.title | Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids | en_US |
| Document type | dc.type | Artículo de revista | |
