Author | dc.contributor.author | Soto, Carolina R. | |
Author | dc.contributor.author | Ortiz, Fernando C. | es_CL |
Author | dc.contributor.author | Vargas, Romina V. | es_CL |
Author | dc.contributor.author | Arroyo, Jorge | es_CL |
Author | dc.contributor.author | Alcayaga Urbina, Julio | es_CL |
Admission date | dc.date.accessioned | 2011-08-26T13:02:33Z | |
Available date | dc.date.available | 2011-08-26T13:02:33Z | |
Publication date | dc.date.issued | 2010-05-02 | |
Cita de ítem | dc.identifier.citation | RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, Volume: 172, Issue: 3, Pages: 114-121, 2010 | es_CL |
Identifier | dc.identifier.issn | 1569-9048 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119270 | |
General note | dc.description | Artículo de publicación ISI | es_CL |
Abstract | dc.description.abstract | Acetylcholine and ATP appear to mediate excitatory transmission between receptor (glomus) cells and
the petrosal ganglion (PG) neuron terminals in the carotid body. In most species these putative transmitters
are excitatory, while inhibitory effects had been reported in the rabbit. We studied the effects of the
application of acetylcholine and ATP to the PG on the carotid nerve activity in vitro. Acetylcholine and ATP
applied to thePGincreased the carotid nerve activity in a dose-dependent manner. Acetylcholine-induced
responses were mimicked by nicotine, antagonized by hexamethonium, and enhanced by atropine.
Bethanechol had no effect on basal activity, but reduced acetylcholine-induced responses. Suramin antagonized
ATP-induced responses, and AMP had little effect on the carotid nerve activity. Our results suggest
that rabbit PG neurons projecting through the carotid nerve are endowed with nicotinic acetylcholine
and purinergic P2 receptors that increase the carotid nerve activity, while simultaneous activation of
muscarinic cholinergic receptors reduce the maximal response evoked by nicotinic cholinergic receptor
activation. | es_CL |
Patrocinador | dc.description.sponsorship | This work was supported by grants 1040638 and 1090157 from
the National Fund for Scientific and Technological Development
(FONDECYT) of Chile. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | ELSEVIER SCIENCE BV | es_CL |
Keywords | dc.subject | Petrosal ganglion | es_CL |
Título | dc.title | Responses induced by acetylcholine and ATP in the rabbit petrosal ganglion | es_CL |
Document type | dc.type | Artículo de revista | |