| Author | dc.contributor.author | Araya Maturana, Ramiro | |
| Author | dc.contributor.author | Delgado Castro, Tomás | es_CL |
| Author | dc.contributor.author | Gárate, Mario | es_CL |
| Author | dc.contributor.author | Ferreira Parker, Jorge | es_CL |
| Author | dc.contributor.author | Pavani, Mario | es_CL |
| Author | dc.contributor.author | Pessoa Mahana, Hernán | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Admission date | dc.date.accessioned | 2012-05-18T19:22:19Z | |
| Available date | dc.date.available | 2012-05-18T19:22:19Z | |
| Publication date | dc.date.issued | 2002-01-29 | |
| Cita de ítem | dc.identifier.citation | Bioorganic & Medicinal Chemistry, 10: 3057–3060, 2002. | es_CL |
| Identifier | dc.identifier.issn | 3057–3060 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119405 | |
| Abstract | dc.description.abstract | Abstract—A set of structurally related compounds incorporating a carbonyl group in the ortho position withregard to a phenol
function were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. The series consists
of 20-hydroxyacetophenone, 40-hydroxyacetophenone 20,50-dihydroxyacetophenone, 4-acetyl-3,3-dimethyl-5-hydroxy-2-morpholino-
2,3-dihydrobenzobfuran, five 4,4-dimethyl-5,8-dioxygenated naphtalene-1-ones and three 4,4-dimethyl-5,8-dioxygenated tetralones.
A tentative structure–activity relationship was found for this family of substances, suggesting that a coplanar ortho-carbonyl-
1,4-hydroquinone motif is able to cause inhibition of cellular respiration. | es_CL |
| Patrocinador | dc.description.sponsorship | This work was supported by FONDECYT Grants No.
1950301, 1981066 and 1000859. We also acknowledge
financial support by the Faculty of Chemical and Pharmaceutical
Sciences, University of Chile, Grant P99–1.
T.D.-C. thanks CONICYT for a fellowship. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Elsevier Science Ltd. | es_CL |
| Título | dc.title | Effects of 4,4-Dimethyl-5,8-dihydroxynaphtalene-1-one and 4,4-Dimethyl-5,8-dihydroxytetralone Derivatives onTumor Cell Respiration | es_CL |
| Document type | dc.type | Artículo de revista | |
