BISBENZYLISOQUINOLINE ALKALOIDS OF LA URELZA SEMPERVZRENS
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The stem bark of Laurelia sempervirens R. et P. (Monimiaceae, subfamily Atherospermoideae) is a rich
source of aporphinoids and has also been shown to contain a complex mixture of unidentified bisbenzylisoquinolines
(1). The dimeric fraction has now been reexamined and its major components identified as
obaberine, thalrugosine, and oxyacanthine. These alkaloids have not been reported previously as constituents
of Monimiaceae, but they belong to the same stereochemical-biogenetic series as isotetrandrine,
isolated from the leaves of L. sempewims (2) as well as from several other Atherospermoideae, and berbamine,
daphnoline, daphnandrine, aromoline, homoaromoline, and more oxidized metabolites of
Atherospenna moscbatum and several Daphnandra species (3).
Patrocinador
This work was supported by the Organization of American States and DICYT (USACH). We thank
Prof. Maurice Shamma (The Pennsylvania State University) for the use of laboratory facilities during the
initial fractionation.
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Brief Reports, Jul-Aug 1985.
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