| Author | dc.contributor.author | Gómez Jeria, Juan | |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Author | dc.contributor.author | Saavedra Aguilar, Juan Carlos | es_CL |
| Admission date | dc.date.accessioned | 2012-05-28T15:18:47Z | |
| Available date | dc.date.available | 2012-05-28T15:18:47Z | |
| Publication date | dc.date.issued | 1987-06-05 | |
| Cita de ítem | dc.identifier.citation | Eur. J. Med. Chem. 22, 433-437, 1987. | es_CL |
| Identifier | dc.identifier.issn | 0223-5234. | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119424 | |
| Abstract | dc.description.abstract | The electronic structure of 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) was calculated at
the CND0/2 level, and the racemic compound was synthesized and found to be hallucinogenic at doses of 4 mg. DON
differs from its similarly active congeners in that a hydrophilic nitro group replaces lipophilic substituents at C-4 of the
benzene ring. The implications for the mechanism of serotonin receptor binding of these drugs are discussed. | es_CL |
| Patrocinador | dc.description.sponsorship | (DIB Project Q 2442) and from the Chilean National Research Fund
(Project 1075). One of us (J.S.G.-J.) thanks Drs. J. Maruani and
A. Toro-LabbC for stimulating discussions. | es_CL |
| Lenguage | dc.language.iso | en | es_CL |
| Publisher | dc.publisher | Elsevier Science | es_CL |
| Keywords | dc.subject | CNDO | es_CL |
| Título | dc.title | A quantum-chemical and experimental study of the hallucinogen (k)- 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) | es_CL |
| Document type | dc.type | Artículo de revista | |
