SINTESIS DE 1-ARIL-2-NITROALQUENOS ANTITUMORALES
Author
Abstract
l-Aryl-2-nitroalkenes can. ba synthesized mest convéniently by refluxing
aromatic aidehydes with nitromethane 01' nitroethane in acetic acid using n-butyla
llIineas a catalyst •.{ In this way' seventeen nev cOIIl'PC'lmdosf this type aad seve-raI
known ana10gues withalkaxy andhalo ring substituents ware prepared. without the
CODcurrent production ol the corref5l'011dingly' substituted benzonitrii_. Moat of
thes!! compounds were- tested in theP-J88 murine 1ympbocytic leuk.emia aseay; {QUr
of them pc~s_sed reproducible antitumor activity, and another five gav& si~ficantiy
increased survival times wtri.ch _re not rept'Oduced
Patrocinador
Este trabajo se realizó con el financiamiento de DICYT (USACH).
Quote Item
Anales Asoc. Quím. Argentina , 70, 283-288, 1982.
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