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Improving Amphetamine Therapeutic Selectivity: N,N-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction

Authordc.contributor.authorSotomayor Zárate, Ramón 
Authordc.contributor.authorJara, Pablo es_CL
Authordc.contributor.authorAraos, Patricio es_CL
Authordc.contributor.authorVinet, Raúl es_CL
Authordc.contributor.authorQuiróz, Gabriel es_CL
Authordc.contributor.authorRenard, Georgina M. es_CL
Authordc.contributor.authorEspinosa, Pedro es_CL
Authordc.contributor.authorHurtado Guzmán, Claudio es_CL
Authordc.contributor.authorMoya, Pablo R. es_CL
Authordc.contributor.authorIturriaga-Vásquez, Patricio es_CL
Authordc.contributor.authorGysling, Katia es_CL
Authordc.contributor.authorReyes Parada, Miguel es_CL
Admission datedc.date.accessioned2015-01-06T15:17:35Z
Available datedc.date.available2015-01-06T15:17:35Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationBasic & Clinical Pharmacology & Toxicology, 2014, 114, 395–399en_US
Identifierdc.identifier.otherDOI: 10.1111/bcpt.12168
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/119902
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractAbstract: Amphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy and obesity. However, their prolonged use has been associated with cardiovascular toxicity and addiction. In recent years, we have studied the pharmacological effects of amphetamine derivatives such as methylthioamphetamine (MTA) and N,Ndimethyl- thioamphetamine, with the aim of improving their therapeutic selectivity. In this work, we show that similarly to MTA, N,N-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic activation. However, unlike MTA, N,N-dimethyl- thioamphetamine does not produce aortic contraction in vitro. Our results show that N,N-dimethyl-thioamphetamine is a drug that retains the dopaminergic effects of amphetamine derivatives but exhibits a lower potential for producing cardiovascular side effects.en_US
Patrocinadordc.description.sponsorshipThis work was funded by MSI Grant No. P10/063- F, CREAS Grant of CONICYT-REGIONAL GORE, Regi on de Valparaíso (No. R12C1001) and FONDECYT Grants No. 111-0392 to KG, No. 109-0037 and 1130185 to MR-P, No. 110-0542 to PI-V and No. 111-21205 to RS-Z.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherNordic Pharmacological Society)en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Títulodc.titleImproving Amphetamine Therapeutic Selectivity: N,N-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contractionen_US
Document typedc.typeArtículo de revistaen_US


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile