Abstract: Amphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy
and obesity. However, their prolonged use has been associated with cardiovascular toxicity and addiction. In recent years,
we have studied the pharmacological effects of amphetamine derivatives such as methylthioamphetamine (MTA) and N,Ndimethyl-
thioamphetamine, with the aim of improving their therapeutic selectivity. In this work, we show that similarly to MTA,
N,N-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of
dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic
activation. However, unlike MTA, N,N-dimethyl- thioamphetamine does not produce aortic contraction in vitro. Our results show
that N,N-dimethyl-thioamphetamine is a drug that retains the dopaminergic effects of amphetamine derivatives but exhibits a
lower potential for producing cardiovascular side effects.
This work was funded by MSI Grant No. P10/063-
F, CREAS Grant of CONICYT-REGIONAL GORE, Regi on
de Valparaíso (No. R12C1001) and FONDECYT Grants No.
111-0392 to KG, No. 109-0037 and 1130185 to MR-P, No.
110-0542 to PI-V and No. 111-21205 to RS-Z.