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Unexpected diastereotopic behaviour in the H-1 NMR spectrum of 1,4-dihydropyridine derivatives triggered by chiral and prochiral centres

Authordc.contributor.authorDa Silva, Jaqueline 
Authordc.contributor.authorBarría, Claudio es_CL
Authordc.contributor.authorJullian Matthaei, Carolina es_CL
Authordc.contributor.authorNavarrete Encina, Patricio es_CL
Authordc.contributor.authorNúñez Vergara, Luis es_CL
Authordc.contributor.authorSquella Serrano, Juan es_CL
Admission datedc.date.accessioned2007-05-18T15:04:54Z
Available datedc.date.available2007-05-18T15:04:54Z
Publication datedc.date.issued2005-01
Cita de ítemdc.identifier.citationJOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 16 (1): 112-115 JAN-FEB 2005en
Identifierdc.identifier.issn0103-5053
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120417
Abstractdc.description.abstract1,4-dihydropyridine derivatives constitute an important pharmacological group for the treatment of cardiovascular diseases. We have synthesised a series 4-(5'-nitro-2'-furyl)-1,4-dihydropyridine derivatives, which were characterised by H-1-NMR. We have found that carboethoxy groups at the C-3 and C-5 on the 1,4-dihydropyridine ring show a much more complex signal in the H-1 NMR spectra, either when C-4 is a pseudo-prochiral or a chiral centre.en
Lenguagedc.language.isoenen
Publisherdc.publisherSOC BRASILEIRA QUIMICAen
Keywordsdc.subjectHANTZSCH 1,4-DIHYDROPYRIDINESen
Títulodc.titleUnexpected diastereotopic behaviour in the H-1 NMR spectrum of 1,4-dihydropyridine derivatives triggered by chiral and prochiral centresen
Document typedc.typeArtículo de revistaen


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