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Authordc.contributor.authorLópez Alarcón, Camilo 
Authordc.contributor.authorSquella Serrano, Juan es_CL
Authordc.contributor.authorNúñez Vergara, Luis es_CL
Authordc.contributor.authorBáez Guerrero, Hernán es_CL
Authordc.contributor.authorCamargo Grandón, Rodrigo es_CL
Admission datedc.date.accessioned2008-08-29T18:09:33Z
Available datedc.date.available2008-08-29T18:09:33Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationRAPID COMMUNICATIONS IN MASS SPECTROMETRY 16(24):2229-2238en
Identifierdc.identifier.issn0951-4198
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120484
Abstractdc.description.abstractA gas chromatography/mass spectrometry (GC/MS) method for the qualitative and quantitative determination of the calcium-channel antagonists C-4-substituted 1,4-dihydropyridines, and their corresponding N-ethyl derivatives, is presented. Also, the electrochemical oxidation and the reactivity of the compounds with alkyl radicals derived from 2,2'-azobis-(2-amidinopropane) were monitored by GC/MS. Mass spectral fragmentation patterns for the C-4-substituted 1,4-dihydropyridine parent drugs were significantly different from those of their oxidation products, generated either by electrochemical oxidation or by reaction with alkyl radicals. However, for N-ethyl-1,4-dihydropyridine compounds it was not possible to detect the final products (pyridinium salts) using these experimental conditions.en
Lenguagedc.language.isoenen
Publisherdc.publisherJOHN WILEYen
Keywordsdc.subjectGas chromatographyen
Títulodc.titleGas chromatography/mass spectrometric study of non-commercial C-4-substituted 1,4-dihydropyridines and their oxidized derivativesen
Document typedc.typeArtículo de revistaen


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