Author | dc.contributor.author | Insuasty, B. A. | |
Author | dc.contributor.author | Torres, H. | es_CL |
Author | dc.contributor.author | Quiroga, J. | es_CL |
Author | dc.contributor.author | Abonia, R. | es_CL |
Author | dc.contributor.author | Rodríguez, R. | es_CL |
Author | dc.contributor.author | Nogeras, N. | es_CL |
Author | dc.contributor.author | López Sánchez, Ángel R. | |
Author | dc.contributor.author | Saitz Barría, Claudio | |
Author | dc.contributor.author | Alvarez, S. L. | |
Author | dc.contributor.author | Zacchino, Susana | |
Admission date | dc.date.accessioned | 2009-04-09T11:44:52Z | |
Available date | dc.date.available | 2009-04-09T11:44:52Z | |
Publication date | dc.date.issued | 2006-06 | |
Cita de ítem | dc.identifier.citation | JOURNAL OF THE CHILEAN CHEMICAL SOCIETY Volume: 51 Issue: 2 Pages: 927-932 Published: JUN 2006 | en |
Identifier | dc.identifier.issn | 0717-9324 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120598 | |
Abstract | dc.description.abstract | The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments such as H-1-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed antifungal properties only against dermatophytes. Among them, those with electron-donor substituents on the 6-phenyl ring inhibited mainly T. rubrum and E. floccosum with MICs between 25-250 mu g/mL and M. canis, M gypseum and T. mentagrophytes with MICs between 50-250 mu g/mL. Structures with electron-withdrawing substituents on the phenyl ring did not show any activities up to 250 mu g/ml. Methyl substituents on the benzimidazole ring seem negatively affect the antifungal behaviour of this series. | en |
Lenguage | dc.language.iso | en | en |
Publisher | dc.publisher | SOCIEDAD CHILENA DE QUIMICA | en |
Keywords | dc.subject | ANTIMICROBIAL ACTIVITY | en |
Título | dc.title | Synthesis, characterization and in vitro antifungal evaluation of novel benzimidazo[1,2-c]quinazolines | en |
Document type | dc.type | Artículo de revista | |