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Nanoparticle-mediated local and remote manipulation of protein aggregation

Authordc.contributor.authorKogan Bocian, Marcelo 
Authordc.contributor.authorBastus, Neus G. es_CL
Authordc.contributor.authorAmigo, Roger es_CL
Authordc.contributor.authorGrillo-Bosch, Dolors es_CL
Authordc.contributor.authorAraya, Eyleen es_CL
Authordc.contributor.authorTuriel, Antonio es_CL
Authordc.contributor.authorLabarta, Amilcar es_CL
Authordc.contributor.authorGiralt, Ernest es_CL
Authordc.contributor.authorPuntes, Víctor F. es_CL
Admission datedc.date.accessioned2009-04-14T11:46:54Z
Available datedc.date.available2009-04-14T11:46:54Z
Publication datedc.date.issued2006-01
Cita de ítemdc.identifier.citationNANO LETTERS Volume: 6 Issue: 1 Pages: 110-115 Published: JAN 2006en
Identifierdc.identifier.issn1530-6984
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120600
Abstractdc.description.abstractThe local heat delivered by metallic nanoparticles selectively attached to their target can be used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this principle to protein aggregates, in particular to the amyloid beta protein (A beta) involved in Alzheimer's disease (AD), a neurodegenerative disease where unnaturally folded A beta proteins self-assemble and deposit forming amyloid fibrils and plaques. We show the possibility to remotely redissolve these deposits and to interfere with their growth, using the local heat dissipated by gold nanoparticles (AuNP) selectively attached to the aggregates and irradiated with low gigahertz electromagnetic fields. Simultaneous tagging and manipulation by AuNP of A beta at different stages of aggregation allow both, noninvasive exploration and dissolution of molecular aggregates.en
Lenguagedc.language.isoenen
Publisherdc.publisherAMER CHEMICAL SOCen
Keywordsdc.subjectALZHEIMERS-DISEASEen
Títulodc.titleNanoparticle-mediated local and remote manipulation of protein aggregationen
Document typedc.typeArtículo de revistaen


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