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Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes

Authordc.contributor.authorFoncea Avila, Rocío 
Authordc.contributor.authorGálvez, Anita es_CL
Authordc.contributor.authorPérez Montes, Viviana es_CL
Authordc.contributor.authorMorales, María Paz es_CL
Authordc.contributor.authorCalixto, Andrea es_CL
Authordc.contributor.authorMeléndez Vergara, Jaime es_CL
Authordc.contributor.authorGonzález Jara, Fabián Rodrigo es_CL
Authordc.contributor.authorDíaz Araya, Guillermo es_CL
Authordc.contributor.authorSapag Hagar, Mario es_CL
Authordc.contributor.authorSugden, Peter H. es_CL
Authordc.contributor.authorLeRoith, Derek es_CL
Authordc.contributor.authorLavandero González, Sergio es_CL
Admission datedc.date.accessioned2010-03-26T13:45:46Z
Available datedc.date.available2010-03-26T13:45:46Z
Publication datedc.date.issued2000-07-05
Cita de ítemdc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(2): 736-744en_US
Identifierdc.identifier.issn0006-291X
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120906
Abstractdc.description.abstractThis study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide turnover, translocation of protein kinase C (PKC) isoforms (alpha, epsilon, and delta) from the soluble to the particulate fraction, activation of phospholipid-dependent and Ca2+-, phospholipid-dependent PKC, and activation of the extracellular-regulated kinase (ERK), IGF-1 attenuated sorbitol-induced cardiomyocyte viability and nuclear DNA fragmentation, These antiapoptotic effects of IGF-1 were blocked by PD098059 (an MEK inhibitor) but not by bisindolylmaleimide I (BIM, a specific PKC inhibitor), The ERK pathway may therefore be an important component in the mechanism whereby IGF-1 exerts its antiapoptotic effect on the cardiomyocyte,en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherACADEMIC PRESS INCen_US
Keywordsdc.subjectInsulin-like growth factor-1en_US
Títulodc.titleExtracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytesen_US
Document typedc.typeArtículo de revistaen_US


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