| Author | dc.contributor.author | Foncea Avila, Rocío | |
| Author | dc.contributor.author | Gálvez, Anita | es_CL |
| Author | dc.contributor.author | Pérez Montes, Viviana | es_CL |
| Author | dc.contributor.author | Morales, María Paz | es_CL |
| Author | dc.contributor.author | Calixto, Andrea | es_CL |
| Author | dc.contributor.author | Meléndez Vergara, Jaime | es_CL |
| Author | dc.contributor.author | González Jara, Fabián Rodrigo | es_CL |
| Author | dc.contributor.author | Díaz Araya, Guillermo | es_CL |
| Author | dc.contributor.author | Sapag Hagar, Mario | es_CL |
| Author | dc.contributor.author | Sugden, Peter H. | es_CL |
| Author | dc.contributor.author | LeRoith, Derek | es_CL |
| Author | dc.contributor.author | Lavandero González, Sergio | es_CL |
| Admission date | dc.date.accessioned | 2010-03-26T13:45:46Z | |
| Available date | dc.date.available | 2010-03-26T13:45:46Z | |
| Publication date | dc.date.issued | 2000-07-05 | |
| Cita de ítem | dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(2): 736-744 | en_US |
| Identifier | dc.identifier.issn | 0006-291X | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120906 | |
| Abstract | dc.description.abstract | This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide turnover, translocation of protein kinase C (PKC) isoforms (alpha, epsilon, and delta) from the soluble to the particulate fraction, activation of phospholipid-dependent and Ca2+-, phospholipid-dependent PKC, and activation of the extracellular-regulated kinase (ERK), IGF-1 attenuated sorbitol-induced cardiomyocyte viability and nuclear DNA fragmentation, These antiapoptotic effects of IGF-1 were blocked by PD098059 (an MEK inhibitor) but not by bisindolylmaleimide I (BIM, a specific PKC inhibitor), The ERK pathway may therefore be an important component in the mechanism whereby IGF-1 exerts its antiapoptotic effect on the cardiomyocyte, | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | ACADEMIC PRESS INC | en_US |
| Keywords | dc.subject | Insulin-like growth factor-1 | en_US |
| Título | dc.title | Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes | en_US |
| Document type | dc.type | Artículo de revista | |
