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Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat

Authordc.contributor.authorOliveri Pérez, Carla Giovanna 
Authordc.contributor.authorOcaranza, María Paz es_CL
Authordc.contributor.authorCampos Bastidas, Ximena es_CL
Authordc.contributor.authorLavandero González, Sergio es_CL
Authordc.contributor.authorJalil Milad, Jorge es_CL
Cita de ítemdc.identifier.citationHYPERTENSION 38(3): 650-654 Part: 2 Suppl. Sen_US
Abstractdc.description.abstractAngiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were measured by fluorometry in homozygous rats (FO and 172) for the Lewis microsatellite allele (LL, low ACE) and for the Brown Norway microsatellite allele (BB, high ACE). Plasma, lung, and aortic ACE activities in F-0 and F-2 were higher in BB rats than in LL rats (P <0.01), whereas left ventricular ACE activity was similar in both genotypes. In contrast, NEP activity in the LL group was higher in the serum, aorta, and lungs in F-0 and F-2 homozygous (P <0.05). Plasma ACE activity was inversely correlated with serum (r=-0.6 and -0.598 in F-0 and F-2, respectively; P <0.03) and lung NEP activities (r=-0.77 in F-0 and r=-0.59 in F-2, P <0.01). Aortic ACE and NEP activities were also correlated (r=-0.696 and -0.584 in F-0 and F-2, respectively; P <0.03). In conclusion, genetically determined high ACE expression in rats is inversely related to tissue NEP activity, which could determine lower angiotensin-(1-7) tissue levels.en_US
Keywordsdc.subjectAngiotensin-converting enzymeen_US
Títulodc.titleAngiotensin I-converting enzyme modulates neutral endopeptidase activity in the raten_US
Document typedc.typeArtículo de revistaen_US

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