| Author | dc.contributor.author | Troncoso Cotal, Rodrigo | |
| Author | dc.contributor.author | Moraga, Francisco | es_CL |
| Author | dc.contributor.author | Chiong Lay, Mario | es_CL |
| Author | dc.contributor.author | Roldán S., Juan | es_CL |
| Author | dc.contributor.author | Bravo Méndez, Roberto | es_CL |
| Author | dc.contributor.author | Valenzuela, Rodrigo | es_CL |
| Author | dc.contributor.author | Díaz Araya, Guillermo | es_CL |
| Author | dc.contributor.author | Campo Sfeir, Andrea Estefanía del | es_CL |
| Author | dc.contributor.author | Sanhueza Muñoz, Carlos Joaquín | es_CL |
| Author | dc.contributor.author | Rodríguez Villarroel, Andrea Elizabeth | es_CL |
| Author | dc.contributor.author | Vukasovic Ramírez, José Luis | es_CL |
| Author | dc.contributor.author | Mellado, Rose Marie | es_CL |
| Author | dc.contributor.author | Greig, Douglas | es_CL |
| Author | dc.contributor.author | Castro, Pablo | es_CL |
| Author | dc.contributor.author | Lavandero González, Sergio | es_CL |
| Admission date | dc.date.accessioned | 2010-04-07T21:12:59Z | |
| Available date | dc.date.available | 2010-04-07T21:12:59Z | |
| Publication date | dc.date.issued | 2009-05 | |
| Cita de ítem | dc.identifier.citation | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 104(5): 374-378 | en_US |
| Identifier | dc.identifier.issn | 1742-7835 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120931 | |
| Abstract | dc.description.abstract | We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. The 6-min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln(27)-> Glu beta(2)-adrenergic receptor polymorphism. Carvedilol significantly increased the left ventricular ejection fraction, while decreasing the heart rate and malondialdehyde plasma concentrations in chronic heart failure patients with the Glu(27)->beta(2)-adrenergic receptor allele. There were however, no significant changes in patients with the Gln(27)->beta(2)-adrenergic receptor variant. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | WILEY-BLACKWELL PUBLISHING | en_US |
| Keywords | dc.subject | BETA(2)-ADRENERGIC RECEPTOR | en_US |
| Título | dc.title | Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol | en_US |
| Document type | dc.type | Artículo de revista | |
