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Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones

Authordc.contributor.authorPagano, Mariana 
Authordc.contributor.authorDemoro, Bruno es_CL
Authordc.contributor.authorToloza, Jeannette es_CL
Authordc.contributor.authorBoiani, Lucía es_CL
Authordc.contributor.authorGonzález, Mercedes es_CL
Authordc.contributor.authorCerecetto, Hugo es_CL
Authordc.contributor.authorOlea Azar, Claudio es_CL
Authordc.contributor.authorNorambuena, Ester es_CL
Authordc.contributor.authorGambino, Dinorah es_CL
Authordc.contributor.authorOtero, Lucía es_CL
Admission datedc.date.accessioned2010-06-08T13:22:00Z
Available datedc.date.available2010-06-08T13:22:00Z
Publication datedc.date.issued2009-12
Cita de ítemdc.identifier.citationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44 (12): 4937-4943en_US
Identifierdc.identifier.issn0223-5234
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/120970
Abstractdc.description.abstractIn the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest parasitic disease burden in the American continent, three series of novel ruthenium complexes of the formula [RuCl2(HL)(2)], [RuCl3(dmso)(HL)] and [RuCl(PPh3)(L)(2)] with bioactive 5-nitrofuryl containing thiosemicarbazones; as ligands (HL neutral, L monoanionic) were synthesized and characterized. Their in vitro growth inhibition activity against Trypanosoma cruzi and the effect of co-ligands in related physicochemical properties i.e. nitro moiety redox potential, lipophilicity and free radical scavenger capacity were evaluated. Results show that although a loss of activity was observed as a consequence of ruthenium complexation, lipophilicity and free radical scavenger capacity of the obtained complexes could be correlated to their trypanocidal effect.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
Keywordsdc.subjectChagas diseaseen_US
Títulodc.titleEffect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazonesen_US
Document typedc.typeArtículo de revistaen_US


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