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Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes

Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorFoncea Avila, Rocío es_CL
Authordc.contributor.authorPérez, V. es_CL
Authordc.contributor.authorSapag Hagar, Mario es_CL
Admission datedc.date.accessioned2011-04-25T12:12:46Z
Available datedc.date.available2011-04-25T12:12:46Z
Publication datedc.date.issued1998-01-30
Cita de ítemdc.identifier.citationFEBS LETTERS 422 (2): 193-196es_CL
Identifierdc.identifier.issn0014-5793
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/121189
Abstractdc.description.abstractIGF-1 increased 2-fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF-I at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, autophosphorylation of the beta-subunit of IGF-1 receptor and inhibition of ERK. When added 1 or 6 h after IGF-I, however, genistein was without effect. IGF-l-stimulated protein synthesis was also significantly inhibited by PD-098059, staurosporine, and rapamycin, but not by wortmannin, in cardiac myocytes. Some inhibitors produced a reduction in cell size. Activation of the ERK cascade by IGF-1 mag be responsible for some of the features associated with cardiac myocyte hypertrophy.es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherELSEVIER SCIENCE BVes_CL
Keywordsdc.subjectGROWTH-FACTOR-Ies_CL
Títulodc.titleEffect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocyteses_CL
Document typedc.typeArtículo de revistaes_CL


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