Second-derivative spectrophotometric assay of bromazepam in pharmaceutical formulations
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A simple, rapid and accurate direct method has been developed for the determination of bromazepam in pharmaceutical formulations using second-derivative absorption spectrophotometry. Methanol was used as the solvent for extracting the drug from the formulations. The calibration graph was a straigh line (r=0.9989), passing through the origin. The proposed method was succesfully applied to determine bromazepam in pharmaceutical formulations and the ingredients commonly found in commercial tablets do not interfere.
Artículo de publicación ISI