Show simple item record

A practical amine-free synthesis of symmetric ureas and thioureas by self-condensation if iso(thio)cyanates

Authordc.contributor.authorJiménez Blanco, José L. 
Authordc.contributor.authorSaitz Barría, Claudio es_CL
Authordc.contributor.authorBenito, Juan M. es_CL
Authordc.contributor.authorOrtíz Mellet, Carmen es_CL
Authordc.contributor.authorFuentes, José es_CL
Authordc.contributor.authorSantoyo González, Francisco es_CL
Authordc.contributor.authorGarcía Fernández, José M. es_CL
Admission datedc.date.accessioned2011-07-18T18:37:19Z
Available datedc.date.available2011-07-18T18:37:19Z
Publication datedc.date.issued1999
Cita de ítemdc.identifier.citationSynthesis Nº 11: 1907-1914es_CL
Identifierdc.identifier.issn0039-7881
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/121385
Abstractdc.description.abstractIsocianates and isothiocyanates are readily transformed into the corresponding symmetric N,N'-disubstituted ureas and thioureas upon treatment with pyridine-water with no formation of side products. Evidence is shown for an amine-free mechanistic pathway, probably involving (thio)carbamic anhydrides as reaction intermediates. The methodology is compatible with in situ generation of the isocyanate precursor from and acyl azide via Curtius rearrangement and with the presence of ester and amide functional groups in the molecule. Examples given include alkyl, aryl and carbohydrate substrates. This procedure allows the high yielding preparation of (thio)ureas in those cases where the related amine is not accessible.es_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherThieme Stuttgartes_CL
Keywordsdc.subjectUreaes_CL
Títulodc.titleA practical amine-free synthesis of symmetric ureas and thioureas by self-condensation if iso(thio)cyanateses_CL
Document typedc.typeArtículo de revistaes_CL


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record