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Effects of intermittent hypoxia on cat petrosal ganglion responses induced by acetylcholine, adenosine 5 '-triphosphate and NaCN

Authordc.contributor.authorIturriaga, Rodrigo 
Authordc.contributor.authorAlcayaga Urbina, Julio es_CL
Admission datedc.date.accessioned2011-03-23T11:34:05Z
Available datedc.date.available2011-03-23T11:34:05Z
Publication datedc.date.issued2007-01-12
Cita de ítemdc.identifier.citationVolume: 1128, Issue: 1, p.: 86-90, 2007en_US
Identifierdc.identifier.issn0006-8993
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123459
Abstractdc.description.abstractExposure to chronic intermittent hypoxia (CIH) for 4 days enhances the cat carotid body (CB) chemosensory responses to acute hypoxia. However, it is not known if CIH enhances the responses of the petrosal ganglion (PG) neurons that innervate the CB chemoreceptor cells. Accordingly, we studied the effects of the CB putative excitatory transmitter acetylcholine (ACh) and adenosine 5´-triphosphate (ATP), and the effects of citotoxic hypoxia (NaCN) applied to the isolated PG from cats exposed to CIH for 4 days. The dose-dependent curve parameters of the frequency of discharges evoked in the carotid sinus nerve by the application of ACh, ATP and NaCN to the isolated PG in control condition were not significantly modified in the CIH-treated cats. Present results suggest that CIH enhances the chemosensory responses to acute hypoxia acting primarily at the chemoreceptor cells, without major changes in the response of PG neurons evoked by the application of putative CB excitatory transmitters to their somata.en_US
Patrocinadordc.description.sponsorshipThis work was supported by grant 1030330 from the National Fund for Scientific and Technological Development of Chile (FONDECYT).en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherELSEVIER SCIENCE BVen_US
Keywordsdc.subjectCarotid bodyen_US
Títulodc.titleEffects of intermittent hypoxia on cat petrosal ganglion responses induced by acetylcholine, adenosine 5 '-triphosphate and NaCNen_US
Document typedc.typeArtículo de revistaen_US


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