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Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent study

Authordc.contributor.authorÁngel Badillo, Bárbara 
Authordc.contributor.authorSantos, José Luis es_CL
Authordc.contributor.authorCarrasco Piña, Elena es_CL
Authordc.contributor.authorAlbala Brevis, Cecilia es_CL
Authordc.contributor.authorPérez Bravo, Francisco es_CL
Admission datedc.date.accessioned2007-04-24T15:15:14Z
Available datedc.date.available2007-04-24T15:15:14Z
Publication datedc.date.issued2004
Cita de ítemdc.identifier.citationEUROPEAN JOURNAL OF EPIDEMIOLOGY 19 (12): 1085-1087 2004en
Identifierdc.identifier.issn0393-2990
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123800
Abstractdc.description.abstractSeveral reports have found a relation between polymorphisms of the vitamin D receptor gene (VDR) and the development of type I diabetes. We have examined the association of three VDR polymorphism with type I diabetes in 59 Chilean case-parents trios. Genotyping for Bsml, Apal and Taq1 polymorphism were performed. Transmission/ disequilbrium tests were used to assess gene-disease associations through the evaluation of allelic transmission to affected offspring. Non-significant increased transmissions of B allele (probability of transmission = 52.5%, p = 0.69), A allele (probability of transmission = 58.4%, p = 0.17) and T allele (probability of transmission = 52.0%, p = 0.77) were estimated in Bsm1, Apa1 and Taq1 sites, respectively. Haplotype-based analyses showed non-significant preferential transmissions (global p = 0.52). The present study does not support the hypothesis of a significant contribution of VDR alleles in the etiology of type I diabetes of Chilean cases.en
Lenguagedc.language.isoenen
Publisherdc.publisherSPRINGERen
Keywordsdc.subjectBONE-MINERAL DENSITYen
Títulodc.titleVitamin D receptor polymorphism and susceptibility to type 1 diabetes in chilean subjects: A case-parent studyen
Document typedc.typeArtículo de revistaen


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