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Community-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking water

Authordc.contributor.authorAraya, Magdalena es_CL
Authordc.contributor.authorOlivares Grohnert, Manuel es_CL
Authordc.contributor.authorPizarro Aguirre, Fernando es_CL
Authordc.contributor.authorLlanos, Adolfo es_CL
Authordc.contributor.authorFigueroa, Guillermo es_CL
Authordc.contributor.authorUauy Dagach-Imbarack, Ricardo 
Admission datedc.date.accessioned2007-04-24T20:38:02Z
Available datedc.date.available2007-04-24T20:38:02Z
Publication datedc.date.issued2004-07
Cita de ítemdc.identifier.citationENVIRONMENTAL HEALTH PERSPECTIVES 112 (10): 1068-1073 JUL 2004en
Identifierdc.identifier.issn0091-6765
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123801
Abstractdc.description.abstractWe assessed gastrointestinal effects in 1,365 adults exposed to either < 0.01 (controls), 2, 4, or 6 mg copper/L of drinking water for 2 months in a randomized, double-blind community-based study. The risk of symptoms increased with increasing Cu exposure and decreased with time. The best model by counting-process analysis included Cu concentration and sex. The risk of symptoms remained significantly higher in women than in men during weeks 1-4 for all concentrations tested; at week I comparison with the < 0.01-mg/L group showed that differences became significant in women at 4 mg/L [relative risk (RR) = 1.53; 95% confidence interval (CI), 1.02-2.05), and in men at 6 mg/L (RR = 1.9; 95% CI, 1.02-2-79). At week 2 for men and week 4 in women, the Cu concentration required to obtain significant differences on symptom report was > 6 mg Cu/L. We conclude that exposure to Cu in drinking water results in gastrointestinal symptoms, which are modulated by Cu concentration, time, and sex.en
Lenguagedc.language.isoenen
Publisherdc.publisherUS DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCEen
Keywordsdc.subjectCHILDRENen
Títulodc.titleCommunity-based randomized double-blind study of gastrointestinal effects and copper exposure in drinking wateren
Document typedc.typeArtículo de revistaen


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