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Confirmation of an acute no-ob served-adverse-effect and low-observed-adverse-effect level for copper in bottled drinking water in a multi-site international study

Authordc.contributor.authorAraya, Magdalena 
Authordc.contributor.authorChen, Bingheng es_CL
Authordc.contributor.authorKlevay, Leslie M. es_CL
Authordc.contributor.authorStrain, J. J. es_CL
Authordc.contributor.authorJohnson, Luann es_CL
Authordc.contributor.authorRobson, Paula es_CL
Authordc.contributor.authorShi, Wei es_CL
Authordc.contributor.authorNielsen, Forrest es_CL
Authordc.contributor.authorZhu, Huigang es_CL
Authordc.contributor.authorOlivares Grohnert, Manuel es_CL
Authordc.contributor.authorPizarro Aguirre, Fernando es_CL
Authordc.contributor.authorHaber, Lynne T. es_CL
Admission datedc.date.accessioned2007-05-24T16:07:00Z
Available datedc.date.available2007-05-24T16:07:00Z
Publication datedc.date.issued2003-12
Cita de ítemdc.identifier.citationREGULATORY TOXICOLOGY AND PHARMACOLOGY 38 (3): 389-399 DEC 2003en
Identifierdc.identifier.issn0273-2300
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123827
Abstractdc.description.abstractIn a double blind, 3 x 3 factorial (volume x dose) study, 70 adult females (18-60 years of age) at four different international sites (total pooled n = 269) were given 100, 150, or 200 ml of bottled drinking water with 0.4, 0.8, or 1.2 mg of copper (Cu) as the sulfate salt once each week. Two additional doses (0 and 1.6mg Cu) were added at the 200ml volume to determine a dose-response relationship and corroborate previously reported results. All subjects completed a questionnaire at 0, 0.25, and I h post-dosing that screened for positive gastrointestinal (GI) effects (nausea, vomiting, abdominal pain, and diarrhea). Nausea was the most prevalent symptom reported and was generally reported within the first 15 min (water volume, p < 0.032; copper dose, p < 0.0001; and water volume x copper interaction, p < 0.97). As volume increased, the effect of Cu-induced nausea decreased; as Cu dose increased, the incidence of nausea increased. At 200 ml, a significant increase in reported incidence of nausea at 0.25 h occurred at 1.2 mg Cu (6 mg Cu/L), indicating a NOAEL of 0.8 mg Cu (4 mg Cu/L) for adult females. These data confirm a previously determined human acute NOAEL for Cu added to distilled water, and provide additional, controlled human data for determining safe concentrations of Cu in drinking water.en
Lenguagedc.language.isoenen
Publisherdc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen
Keywordsdc.subjectEXPOSUREen
Títulodc.titleConfirmation of an acute no-ob served-adverse-effect and low-observed-adverse-effect level for copper in bottled drinking water in a multi-site international studyen
Document typedc.typeArtículo de revistaen


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