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Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile

Authordc.contributor.authorPérez Bravo, Francisco es_CL
Authordc.contributor.authorFuentes, M. es_CL
Authordc.contributor.authorÁngel Badillo, Bárbara es_CL
Authordc.contributor.authorSánchez, H. es_CL
Authordc.contributor.authorCarrasco, Elena es_CL
Authordc.contributor.authorSantos, J. L. es_CL
Authordc.contributor.authorLera Marques, Lydia 
Authordc.contributor.authorAlbala Brevis, Cecilia es_CL
Admission datedc.date.accessioned2009-06-08T17:42:35Z
Available datedc.date.available2009-06-08T17:42:35Z
Publication datedc.date.issued2006-12
Cita de ítemdc.identifier.citationACTA DIABETOLOGICA Volume: 43 Issue: 4 Pages: 93-98 Published: DEC 2006en
Identifierdc.identifier.issn0940-5429
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123880
Abstractdc.description.abstractThe aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations. A sample of 96 urban Aymara and 111 urban Mapuche subjects aged 20-80 years were recruited for this cross-sectional study. Glucose, insulin and lipid profile were measured in fasting plasma samples. Insulin resistance was estimated through the HOMA-IR model. FABP2 Ala54Thr genotypes were determined by PCR followed by RFLP analysis. The allele frequency of Thr54 variant was estimated as 18.2% in Aymara subjects, which is one of the lowest reported to date. The corresponding frequency in Mapuche subjects was 31.9% (p < 0.002). Regarding genotype-phenotype associations, no significant differences were found in any of the anthropometric or metabolic variables according to Ala54Thr genotypes. After adjustment by BMI and metabolic variables through a logistic regression analysis, the association of the FABP2 polymorphism with ethnic group persisted (Mapuche group: OR=2.37, 95% CI 1.319-4.277, p=0.004) It is unlikely that Ala54Thr polymorphism of the FABP2 gene plays a relevant role in obesity and insulin resistance in Chilean ethnic groups.en
Lenguagedc.language.isoenen
Publisherdc.publisherSPRINGERen
Keywordsdc.subjectDIABETES-MELLITUSen
Títulodc.titleLack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chileen
Document typedc.typeArtículo de revistaen


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