Show simple item record

Prenatal undernutrition decreases the sensitivity of the pituitary-adrenal axis in rat, as revealed by subcutaneous and intra-paraventricular dexamethasone challenges

Authordc.contributor.authorNavarrete, Mario 
Authordc.contributor.authorNúñez, Héctor es_CL
Authordc.contributor.authorRuiz, Samuel es_CL
Authordc.contributor.authorSoto Moyano, Rubén es_CL
Authordc.contributor.authorValladares Boasi, Luis es_CL
Authordc.contributor.authorWhite Ortiz, Allan es_CL
Authordc.contributor.authorPérez, Hernán es_CL
Admission datedc.date.accessioned2009-06-23T16:58:50Z
Available datedc.date.available2009-06-23T16:58:50Z
Publication datedc.date.issued2007-05
Cita de ítemdc.identifier.citationNEUROSCIENCE LETTERS, V.: 419, issue: 2, p.: 99-103, MAY 29 2007.en
Identifierdc.identifier.issn0304-3940
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/123899
Abstractdc.description.abstractPrenatal undernutrition is known to disturb the hypothalamo-pituitary-adrenal (HPA) axis, possibly through the programming of decreased expression of hypothalamic and pituitary glucocorticoid receptors. To test this hypothesis, we examined the corticosterone response to moderate subcutaneous (100 g/kg) and intra-paraventricular (50 pmol, bilaterally) dexamethasone (DEX) challenges in normal eutrophic and prenatally undernourished young rats. Undernutrition was induced during fetal life by restricting the diet of pregnant mothers to 10 g daily, while mothers of eutrophic rats received the same diet ad libitum. At day 40 of postnatal life (i) undernourished rats showed increased plasma corticosterone concentration compared to normals; and (ii) subcutaneous and intra-paraventricular administrations of DEX led to reduced corticosterone levels in normal and undernourished animals, the effect of DEX (administered either peripherally or centrally) being significantly lower in the latter group. Results suggest that the low sensitivity of the HPA axis to DEX as well as the increased plasma corticosterone observed in prenatally undernourished rats could be due to the already reported glucocorticoid receptor underexpression found in the hypothalamus and pituitary of in utero undernourished animals, but alternative explanations involving central noradrenergic adaptive changes could also be possible. © 2007 Elsevier Ireland Ltd. All rights reserved.en
Patrocinadordc.description.sponsorshipThis study was supported by grant no. 1030626 from Fondecyten
Lenguagedc.language.isoenen
Publisherdc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSEen
Keywordsdc.subjectPrenatal undernutritionen
Títulodc.titlePrenatal undernutrition decreases the sensitivity of the pituitary-adrenal axis in rat, as revealed by subcutaneous and intra-paraventricular dexamethasone challengesen
Document typedc.typeArtículo de revistaen


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record