|Author||dc.contributor.author||Olivares Grohnert, Manuel||es_CL
|Author||dc.contributor.author||Pizarro Aguirre, Fernando||
|Cita de ítem||dc.identifier.citation||,Am J Clin Nutr, Vol. 88,(suppl):859S–62S, 2008||en_US
|Identifier||dc.identifier.issn||Print ISSN: 0002-9165 Online ISSN: 1938-3207||
|Abstract||dc.description.abstract||Serum or plasma copper and ceruloplasmin concentrations are the
most widely used laboratory indicators to evaluate copper status.
Both indicators are decreased in moderate or severe copper deficiency.
The activity of several cuproenzymes is decreased in mild
copper deficiency. However, their use is limited by the nonexistence
of standardized assays and high interindividual variability and because
some of these indicators are affected by other conditions.
Recently, it was shown that the protein expression of the copper
chaperone for superoxide dismutase (CCS) is increased in erythrocytes
of rodents with mild copper deficiency. However, no traditional
laboratory indicators have been identified as potential early
markers of copper excess. It is possible that the biomarkers studied
so far are not sensitive enough to detect an increase in body copper
before the appearance of functional or clinical effects or that the
homeostatic mechanisms are so strong that no significant changes in
body copper occur with mild-to-moderate copper exposure. The
identification of appropriate biomarkers for early detection of an
increase in body copper represents a major challenge for further
research, and the development of new approaches, such as network
biology, allows us to search and propose new candidates to be studied.
Recently, we found thatCCSmRNAabundance in mononuclear
blood cells significantly decreased after copper supplementation.
The usefulness of this indicator to detect an increase in body copper
should be assessed in clinical trials.||en_US
|Publisher||dc.publisher||The American Society for Nutrition||en_US
|Título||dc.title||Present situation of biomarkers for copper status 1-3||en_US
|Document type||dc.type||Artículo de revista||en_US