Author | dc.contributor.author | Torres, Crístian | |
Author | dc.contributor.author | Antileo, Elmer | es_CL |
Author | dc.contributor.author | Epuñán, María José | es_CL |
Author | dc.contributor.author | Pino, Ana María | es_CL |
Author | dc.contributor.author | Valladares Boasi, Luis | es_CL |
Author | dc.contributor.author | Sierralta, Walter | es_CL |
Admission date | dc.date.accessioned | 2010-01-20T19:57:56Z | |
Available date | dc.date.available | 2010-01-20T19:57:56Z | |
Publication date | dc.date.issued | 2008-06 | |
Cita de ítem | dc.identifier.citation | ONCOLOGY REPORTS, Volume: 19, Issue: 6, Pages: 1597-1603, 2008 | en_US |
Identifier | dc.identifier.issn | 1021-335X | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/123933 | |
Abstract | dc.description.abstract | A cyclic peptide derived from the active domain of
α-fetoprotein (AFP) significantly inhibited the proliferation of
MCF7 cells stimulated with the epidermal growth factor (EGF)
or estradiol (E2). The action of these three agents on cell
growth was independent of the presence of calf serum in the
culture medium. Our results demonstrated that the cyclic
peptide interfered markedly with the regulation of MAPK by
activated c-erbB2. The cyclic peptide showed no effect on the
E2-stimulated release of matrix metalloproteinases 2 and 9 nor
on the shedding of heparin-binding EGF into the culture
medium. We propose that the AFP-derived cyclic peptide
represents a valuable novel antiproliferative agent for treating
breast cancer. | en_US |
Patrocinador | dc.description.sponsorship | This study was
supported by Fondecyt Chile, Grant 1040881. | en_US |
Lenguage | dc.language.iso | en | en_US |
Publisher | dc.publisher | PROFESSOR D A SPANDIDOS | en_US |
Keywords | dc.subject | MEMBRANE ESTROGEN-RECEPTORS | en_US |
Título | dc.title | A cyclic peptide derived from alpha-fetoprotein inhibits the proliferative effects of the epidermal growth factor and estradiol in MCF7 cells | en_US |
Document type | dc.type | Artículo de revista | |