Author | dc.contributor.author | Castillo Lancellotti, C. | |
Author | dc.contributor.author | Tur Marí, J. A. | es_CL |
Author | dc.contributor.author | Uauy Dagach-Imbarack, Ricardo | es_CL |
Admission date | dc.date.accessioned | 2012-05-28T19:56:18Z | |
Available date | dc.date.available | 2012-05-28T19:56:18Z | |
Publication date | dc.date.issued | 2012 | |
Cita de ítem | dc.identifier.citation | Nutr Hosp. 2012;27(1):90-102 | es_CL |
Identifier | dc.identifier.issn | 0212-1611 | |
Identifier | dc.identifier.other | DOI:10.3305/nh.2012.27.1.5432 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/124004 | |
Abstract | dc.description.abstract | Background: Folate and other B complex vitamins play
important roles in the synthesis of DNA, gene expression,
homocysteine detoxification and synthesis of neurotransmitters
necessary for the maintenance of cognitive function.
Aim: Systematic literature review of benefit and/ risks
of folate and related nutrients in cognitive function in
older adults.
Material and methods: “Medline via Pubmed syste -
matic review” of selected articles from years 2010 and
May 2011 and references of the selected articles looking
specifically at serum and erythrocyte folate levels, and
folate intake and cognitive function in older adults.
Results: Twelve cross-sectional studies, six cohort studies
and six randomized double-blind clinical studies that
met pre-established criteria were selected for analysis.
Conclusions: This review doesn’t support a benefit
from folic acid supplementation on cognitive function in
the elderly. Whereas low folate serum levels may be
related to increased risk of cognitive impairment and
high levels associated with low levels of vitamin B12 can
contribute a further deterioration, it is suggested as precautory
measure to re-examine the present level of food
fortification with folic acid to maximize benefits and limit
potential risks. | es_CL |
Lenguage | dc.language.iso | es | es_CL |
Keywords | dc.subject | Ácido fólico | es_CL |
Título | dc.title | Revisión sistemática del efecto de los folatos y otros nutrientes relacionados en la función cognitiva del adulto mayor | es_CL |
Title in another language | dc.title.alternative | EFFECT OF FOLATE AND RELATED NUTRIENTS ON COGNITIVE FUNCTION IN OLDER PEOPLE; SYSTEMATIC REVIEW | es_CL |
Document type | dc.type | Artículo de revista | |