Relationship of Adiposity and Insulin Resistance Mediated by Inflammation in a Group of Overweight and Obese Chilean Adolescents
Author
dc.contributor.author
Reyes Jedlicki, Marcela
Author
dc.contributor.author
Gahagan, Sheila
es_CL
Author
dc.contributor.author
Díaz Bustos, Erik
es_CL
Author
dc.contributor.author
Blanco, Estela
es_CL
Author
dc.contributor.author
Leiva, Laura
es_CL
Author
dc.contributor.author
Lera Marques, Lydia
es_CL
Author
dc.contributor.author
Burrows, Raquel
es_CL
Admission date
dc.date.accessioned
2014-01-02T19:54:36Z
Available date
dc.date.available
2014-01-02T19:54:36Z
Publication date
dc.date.issued
2011
Cita de ítem
dc.identifier.citation
Nutrition Journal 2011, 10:4
en_US
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/124030
Abstract
dc.description.abstract
The mild chronic inflammatory state associated with obesity may be an important link between adiposity and
insulin resistance (IR). In a sample of 137 overweight and obese Chilean adolescents, we assessed associations
between high-sensitivity C-reactive protein (hs-CRP), IR and adiposity; explored sex differences; and evaluated
whether hs-CRP mediated the relationship between adiposity and IR. Positive relationships between hs-CRP, IR and
2 measures of adiposity were found. Hs-CRP was associated with waist circumference (WC) in boys and fat mass
index (FMI) in girls. Using path analysis, we found that hs-CRP mediated the relationship between adiposity (WC
and FMI) and the homeostatic model assessment of insulin resistance (HOMA-IR) (p < 0.05) in both sexes. Our
novel finding is that inflammation statistically mediated the well described link between increased adiposity and IR.