No Evidence for an Association Between Genetic Polymorphisms of
Santos, José Luis
Pérez Bravo, Francisco
Martínez, J. A.
Albala Brevis, Cecilia
Cita de ítem
Nutrition 18:255–258, 2002
Artículo de publicación ISI.
OBJECTIVE: We assessed the association between Gln27Glu and Trp64Arg genetic polymorphisms of the
2 (ADRB2) and 3 (ADRB3) adrenergic receptor genes with body mass index and other cardiovascular
METHODS: In a cross-sectional study, adult Aymara subjects (n 152) living in the Andean regions of
northern Chile were characterized with respect to their ADRB2 and ADRB3 genotypes, body mass index,
plasma leptin and insulin levels, fasting glucose concentration, blood pressure, and plasma lipid profile.
RESULTS: The frequency of the Glu27 allele of the ADRB2 gene was estimated to be 0.04, and the allele
frequency of the Arg64 variant of the ADRB3 gene was estimated as 0.13. No associations were found
between the Trp64Arg polymorphism of the ADRB3 gene and body mass index or other cardiovascular
risk factors. The small number of subjects with the allele encoding Glu27 in the ADRB2 gene seriously
limited the analysis of the association between genotype and phenotype with the use of this polymorphism,
although no clear associations were found.
CONCLUSION: We found insufficient evidence to support an association between polymorphisms
Gln27Glu and Trp64Arg of the ADRB2 and ADRB3 genes, respectively, with body mass index and other
cardiovascular risks in the rural Aymara population from Chile.