Show simple item record

No Evidence for an Association Between Genetic Polymorphisms of

Authordc.contributor.authorSantos, José Luis 
Authordc.contributor.authorPérez Bravo, Francisco es_CL
Authordc.contributor.authorMartínez, J. A. es_CL
Authordc.contributor.authorMontalvo, Domingo es_CL
Authordc.contributor.authorAlbala Brevis, Cecilia es_CL
Authordc.contributor.authorCarrasco, Elena es_CL
Admission datedc.date.accessioned2014-01-08T15:07:44Z
Available datedc.date.available2014-01-08T15:07:44Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationNutrition 18:255–258, 2002en_US
Identifierdc.identifier.otherPII S0899-9007(01)00752-3
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/124048
General notedc.descriptionArtículo de publicación ISI.en_US
Abstractdc.description.abstractOBJECTIVE: We assessed the association between Gln27Glu and Trp64Arg genetic polymorphisms of the 2 (ADRB2) and 3 (ADRB3) adrenergic receptor genes with body mass index and other cardiovascular risk factors. METHODS: In a cross-sectional study, adult Aymara subjects (n 152) living in the Andean regions of northern Chile were characterized with respect to their ADRB2 and ADRB3 genotypes, body mass index, plasma leptin and insulin levels, fasting glucose concentration, blood pressure, and plasma lipid profile. RESULTS: The frequency of the Glu27 allele of the ADRB2 gene was estimated to be 0.04, and the allele frequency of the Arg64 variant of the ADRB3 gene was estimated as 0.13. No associations were found between the Trp64Arg polymorphism of the ADRB3 gene and body mass index or other cardiovascular risk factors. The small number of subjects with the allele encoding Glu27 in the ADRB2 gene seriously limited the analysis of the association between genotype and phenotype with the use of this polymorphism, although no clear associations were found. CONCLUSION: We found insufficient evidence to support an association between polymorphisms Gln27Glu and Trp64Arg of the ADRB2 and ADRB3 genes, respectively, with body mass index and other cardiovascular risks in the rural Aymara population from Chile.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherElsevier Science Inc.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectbody mass index, adrenergic receptor genes, polymorphism, geneticsen_US
Títulodc.titleNo Evidence for an Association Between Genetic Polymorphisms ofen_US
Document typedc.typeArtículo de revistaen_US


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile