Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system
Author
dc.contributor.author
Suazo, José
Author
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Hodgson, María Isabel
es_CL
Author
dc.contributor.author
Obregón, Ana María
es_CL
Author
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Valladares, Macarena
es_CL
Author
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Weisstaub Nuta, Sergio
es_CL
Author
dc.contributor.author
Amador, Paola
es_CL
Author
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Santos, José Luis
es_CL
Admission date
dc.date.accessioned
2014-01-10T14:54:32Z
Available date
dc.date.available
2014-01-10T14:54:32Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
J Pediatr Endocr Met 2013; 26(11-12): 1131–1139
en_US
Identifier
dc.identifier.other
10.1515/jpem-2013-0084
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/124060
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Metabolic syndrome (MS) related to adult type 2
diabetes mellitus and cardiovascular disease is prevalent
among obese children/adolescents. Genetic variants of
the leptin-melanocortin system have been associated with
components of MS. The aim of our study is to estimate the
prevalence of MS (according to Cook’s criteria) in a Chilean
cross-sectional sample of 259 obese children (47.1% girls,
aged 6–12 years), and to assess the association between
common genetic variants of leptin-melanocortin pathway
genes (LEP, LEPR, POMC, MC3R and MC4R) with components
of the MS using logistic regression. We observed an
overall MS prevalence of 26.3% (32.2% in girls and 21.1%
in boys) in obese Chilean children. No associations were
detected between genetic variants of leptin-melanocortin
genes and MS components. MS prevalence among
our obese children sample is similar to those previously
described in Chile, demonstrating the increased risk of
diseases in adulthood that obese children carry.