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Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system

Authordc.contributor.authorSuazo, José 
Authordc.contributor.authorHodgson, María Isabel es_CL
Authordc.contributor.authorObregón, Ana María es_CL
Authordc.contributor.authorValladares, Macarena es_CL
Authordc.contributor.authorWeisstaub Nuta, Sergio es_CL
Authordc.contributor.authorAmador, Paola es_CL
Authordc.contributor.authorSantos, José Luis es_CL
Admission datedc.date.accessioned2014-01-10T14:54:32Z
Available datedc.date.available2014-01-10T14:54:32Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationJ Pediatr Endocr Met 2013; 26(11-12): 1131–1139en_US
Identifierdc.identifier.other10.1515/jpem-2013-0084
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/124060
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractMetabolic syndrome (MS) related to adult type 2 diabetes mellitus and cardiovascular disease is prevalent among obese children/adolescents. Genetic variants of the leptin-melanocortin system have been associated with components of MS. The aim of our study is to estimate the prevalence of MS (according to Cook’s criteria) in a Chilean cross-sectional sample of 259 obese children (47.1% girls, aged 6–12 years), and to assess the association between common genetic variants of leptin-melanocortin pathway genes (LEP, LEPR, POMC, MC3R and MC4R) with components of the MS using logistic regression. We observed an overall MS prevalence of 26.3% (32.2% in girls and 21.1% in boys) in obese Chilean children. No associations were detected between genetic variants of leptin-melanocortin genes and MS components. MS prevalence among our obese children sample is similar to those previously described in Chile, demonstrating the increased risk of diseases in adulthood that obese children carry.en_US
Lenguagedc.language.isoenen_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectassociationen_US
Títulodc.titlePrevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin systemen_US
Document typedc.typeArtículo de revistaen_US


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile