Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors
Author
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Burrows, Raquel
Author
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Correa Burrows, Paulina
Author
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Reyes Jedlicki, Marcela
Author
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Blanco, Estela
Author
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Albala Brevis, Cecilia
Author
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Gahagan, Sheila
Admission date
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2015-10-27T18:59:14Z
Available date
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2015-10-27T18:59:14Z
Publication date
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2015
Cita de ítem
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Journal of Diabetes Research Volume 2015, Article ID 783296, 8 pages
en_US
Identifier
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DOI: 10.1155/2015/783296
Identifier
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https://repositorio.uchile.cl/handle/2250/134703
General note
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Artículo de publicación ISI
en_US
Abstract
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Objective. To determine the optimal cutoff of the homeostasis model assessment-insulin resistance (HOMA-IR) for diagnosis of the metabolic syndrome (MetS) in adolescents and examine whether insulin resistance (IR), determined by this method, was related to genetic, biological, and environmental factors. Methods. In 667 adolescents (16.8 +/- 0.3y), BMI, waist circumference, glucose, insulin, adiponectin, diet, and physical activity were measured. Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM) was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses. Results. Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR. Conclusions. In adolescents, HOMA-IR >= 2.6 was associated with greater cardiometabolic risk.
en_US
Patrocinador
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National Heart Lung and Blood Institute (NHLBI)
National Institutes of Health (USA)
R01HL088530-2980925
Advanced Human Capital Program
79140003
National Council for Scientific Research and Technology (CONICYT) (Chile)