Low Leptin Availability as a Risk Factor for Dementia in Chilean Older People
Author
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Albala Brevis, Cecilia
Author
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Ángel Badillo, Bárbara Karen
Author
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Lera Marques, Lydia
Author
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Sánchez Reyes, Hugo
Author
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Márquez, Carlos
Author
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Fuentes Guglielmetti, Patricio Alberto
Admission date
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2017-03-01T19:12:33Z
Available date
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2017-03-01T19:12:33Z
Publication date
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2016
Cita de ítem
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Dementia and Geriatric Cognitive Disorders. Extra Volumen: 6 Número: 2 Páginas: 295-302
es_ES
Identifier
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1664-5464
Identifier
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https://repositorio.uchile.cl/handle/2250/142836
Abstract
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Objective: The aim was to study the role of leptin in the development of dementia. Methods: Follow-up of the ALEXANDROS cohorts, with baseline measurements in 2000. From 1,136 available subjects free of dementia at baseline, 667 subjects had frozen baseline blood samples for measuring leptin and soluble leptin receptor (sOB-R). The free leptin index (FLI) was calculated as the ratio of leptin to sOB-R. Dementia was defined as an MMSE score <22 and a score >5 in the Pfeffer Activities Questionnaire. Results: After 15 years of follow-up, 42 incident cases of dementia were identified. No difference in serum leptin was observed between people with and without dementia, but sOB-R was higher in demented than in nondemented subjects (sOB-R: 44.94 +/- 23.97 vs. 33.73 +/- 21.13 ng/ml). The adjusted risk for dementia increased, the higher the log sOB (hazard ratio = 3.58; 95% CI 1.72-7.45, p = 0.001). Conclusion: Lower availability of free leptin was found in demented than in nondemented people, suggesting a role of leptin in cognition. (C) 2016 The Author(s) Published by S. Karger AG, Basel