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Glucocorticoid resistance in chronic diseases

Authordc.contributor.authorRodriguez, Juan 
Authordc.contributor.authorMonsalves Álvarez, Matías 
Authordc.contributor.authorHenriquez, Sandra 
Authordc.contributor.authorLlanos Silva, Miguel 
Authordc.contributor.authorTroncoso Cotal, Rodrigo 
Admission datedc.date.accessioned2017-10-31T19:23:44Z
Available datedc.date.available2017-10-31T19:23:44Z
Publication datedc.date.issued2016-11
Cita de ítemdc.identifier.citationSteroids 115 (2016) 182–192es_ES
Identifierdc.identifier.other10.1016/j.steroids.2016.09.010
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/145421
Abstractdc.description.abstractGlucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are extensively used to suppress allergic, inflammatory, and immune disorders. Although glucocorticoids are highly effective for therapeutic purposes, some patients chronically treated with glucocorticoids can develop reduced glucocorticoid sensitivity or even resistance, increasing patient vulnerability to exaggerated inflammatory responses. Glucocorticoid resistance can occur in several chronic diseases, including asthma, major depression, and cardiovascular conditions. In this review, we discuss the complexity of the glucocorticoid receptor and the potential role of glucocorticoid resistance in the development of chronic diseases.es_ES
Patrocinadordc.description.sponsorshipThis work was supported by the Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile [FONDECYT 11130285 to R.T, 1130106 to M.LL., and FONDAP 15130011 to R.T.].es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevier Sciencees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceSteroidses_ES
Keywordsdc.subjectCortisoles_ES
Keywordsdc.subjectCorticosteronees_ES
Keywordsdc.subjectInflammationes_ES
Keywordsdc.subjectGlucocorticoid receptores_ES
Títulodc.titleGlucocorticoid resistance in chronic diseaseses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorffces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile