Development of a Kinetic Spectrophotometric Method for the Determination of Ciclopirox Olamine in Pharmaceutical Sample
Author
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Nacaratte Guajardo, Fallon
Author
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Toral Ponce, María
Author
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Soto, César
Admission date
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2017-12-05T19:41:20Z
Available date
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2017-12-05T19:41:20Z
Publication date
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2016
Cita de ítem
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J. Chil. Chem. Soc., 61, Nº 3 (2016)
es_ES
Identifier
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0717-9707
Identifier
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https://repositorio.uchile.cl/handle/2250/146020
Abstract
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A simple and sensitive kinetic spectrophotometric method was developed for the determination of ciclopirox olamine in pharmaceutical formulations (cream). The method is based on the oxidation of ciclopirox olamine with KMnO4 in alkaline medium to form K2MnO4, a bluish green color compound, at ionic strength controlled and room temperature. The reaction is monitored measuring the rate of change of absorbance at 610 nm. The absorbance-concentration plot corresponding to synthetic pharmaceutical samples (cream) was rectilinear, over the range of 0.32 - 10.0 mu g mL(-1), with detection and quantification limits of 0.095 mu g mL(-1) and 0.32 mu g mL(-1), respectively. Different experimental parameters affecting the development and stability of the reaction product were carefully studied via factorial screening and optimized by univariate method. The determination of ciclopirox olamine by the fixed time method is feasible and more advantageous with the calibration equation obtained at 30 min. The proposed method was validated for the application of the determination of the drug in pharmaceutical sample (cream)
es_ES
Patrocinador
dc.description.sponsorship
Fondo Nacional de Investigacion en Ciencia y Tecnologia (FONDECYT) 1130398
CONICYT doctoral fellowship 21120686