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Inter-session reliability of short-interval intracortical inhibition measured by threshold tracking TMS

Authordc.contributor.authorMatamala, José Manuel 
Authordc.contributor.authorHowells, James 
Authordc.contributor.authorDharmadasa, Thanuja 
Authordc.contributor.authorTrinh, Terry 
Authordc.contributor.authorMa, Yan 
Authordc.contributor.authorLera Marques, Lydia 
Authordc.contributor.authorVucic, Steve 
Authordc.contributor.authorBurke, David 
Authordc.contributor.authorKiernan, Matthew C. 
Cita de ítemdc.identifier.citationNeuroscience Letters 674 (2018) 18–23es_ES
Abstractdc.description.abstractPaired-pulse transcranial magnetic stimulation (TMS) using fixed test stimuli suffers from marked variability of the motor evoked potential (MEP) amplitude. Threshold tracking TMS (TT-TMS) was introduced to overcome this problem. The aim of this work was to describe the absolute and relative reliability of short-interval intracortical inhibition (SICI) using TT-TMS. Cortical excitability studies were performed on twenty-six healthy subjects over three sessions (two recordings on the same day and one seven days apart), with MEPs recorded over abductor pollicis brevis. Reliability was established by calculating the standard error of the measurements (SEm), minimal detectable change (MDC) and intraclass correlation coefficient (ICC). Resting motor threshold and averaged SICI presented the lowest SEm and highest ICCs. SICI at 1 ms showed a higher SEm than SICI at 3 ms, suggesting different physiological processes, but averaging SICI over a number of intervals greatly increases the reproducibility. The variability was lower for tests undertaken at the same time of day seven days apart compared to tests performed on the same day, and in both instances the ICC for averaged SICI was >= 0.81. The MDC in averaged SICI was reduced from 6.7% to 2% if the number of subjects was increased from one to eleven. In conclusion, averaged SICI is the most reproducible variable across paired-pulse TT-TMS measures, showing an excellent ICC. It is recommended that, in longitudinal studies, testing be performed at the same time of day and that changes in cortical excitability should be measured and averaged over a number of interstimulus intervals to minimise variability.es_ES
Patrocinadordc.description.sponsorshipNational Health and Medical Research Council of Australia Program Grant 1037746 International Federation of Clinical Neurophysiology (IFCN) Research Scholarship Becas-Chile Scholarship (CONICYT) Clinica Alemana de Santiago University of Sydney Australian Postgraduate Award Bill Gole Fellowship from the Motor Neurone Disease Research Institute of Australiaes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceNeuroscience Letterses_ES
Keywordsdc.subjectMinimal detectable changeses_ES
Keywordsdc.subjectThreshold tracking transcranial magnetic stimulationes_ES
Keywordsdc.subjectMotor evoked potentialses_ES
Keywordsdc.subjectShort-interval intracortical inhibitiones_ES
Títulodc.titleInter-session reliability of short-interval intracortical inhibition measured by threshold tracking TMSes_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile