Chitosan/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties
Author
dc.contributor.author
Orellana, Sandra L.
Author
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Giacaman, Annesi
Author
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Vidal, Alejandra
Author
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Morales, Carlos
Author
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Oyarzún Ampuero, Felipe
Author
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Lisoni, Judit G.
Author
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Henríquez Baez, Carla
Author
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Moran Trujillo, Luis
Author
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Concha Nordemann, Miguel
Author
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Moreno Villoslada, Ignacio
Admission date
dc.date.accessioned
2018-09-06T16:47:38Z
Available date
dc.date.available
2018-09-06T16:47:38Z
Publication date
dc.date.issued
2018-04
Cita de ítem
dc.identifier.citation
Pure Appl. Chem. 2018; 90(5): 901–911
es_ES
Identifier
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10.1515/pac-2016-1111
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/151510
Abstract
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The formation of ultralight, highly porous solid materials (porosity higher than 99 %) containing equivalent molar amounts of chitosan (CS) and chondroitin sulfate (ChS) is presented. First, we show protocols to produce colloidal suspensions of assembled polymer nanocomplexes by simultaneously mixing equimolar amounts of the oppositely charged polysaccharides, preventing macroprecipitation. The colloidal suspensions were then freeze-dried to form the active aerogels. Apparent density in the order of 10(0)-10(1) mg/cm(3) was achieved. The materials show low stiffness (Young's modulus of about 2 kPa), which make them easy to handle for clinical applications, and easy to compress, pack, store and transport. These characteristics promote them as cheap, safe and biodegradable materials able to be used for several therapeutic purposes, such as wound healing.
es_ES
Patrocinador
dc.description.sponsorship
FONDECYT Regular
1150899
1161450
FONDECYT Iniciacion
11150919
Fondecyt Postdoctorado
3110153
CONICYT-FONDAP
15130011
Gobierno Regional de Los Rios
FIC-R-2011
FIC-R 2012-117