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Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats

Authordc.contributor.authorQuiroz, Gabriel 
Authordc.contributor.authorGuerra-Díaz, Nicolás 
Authordc.contributor.authorIturriaga-Vásquez, Patricio 
Authordc.contributor.authorRivera Meza, Mario 
Authordc.contributor.authorQuintanilla González, María Elena 
Authordc.contributor.authorSotomayor Zárate, Ramón 
Admission datedc.date.accessioned2018-11-07T21:01:42Z
Available datedc.date.available2018-11-07T21:01:42Z
Publication datedc.date.issued2018-09
Cita de ítemdc.identifier.citationBehavioural Brain Research Volumen: 349 Páginas: 169-176es_ES
Identifierdc.identifier.other10.1016/j.bbr.2018.04.038
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/152475
Abstractdc.description.abstractAlcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol dependence. In this work, we assess the effectiveness of four doses of erysodine (1.5, 2.0, 4.0 or 8.0 mg/kg/day, i.p.), a competitive antagonist of nAChRs, on voluntary ethanol consumption behavior in alcohol-preferring UChB rats, administered during three consecutive days. Results show that erysodine administration produces a dose-dependent reduction in ethanol consumption respect to saline injection (control group). The highest doses of erysodine (4 and 8 mg/kg) reduce (45 and 66%, respectively) the ethanol intake during treatment period and first day of post-treatment compared to control group. While, the lowest doses of erysodine (1.5 and 2 mg/kg) only reduce ethanol intake during one day of treatment period. These effective reductions in ethanol intake were 23 and 29% for 1.5 and 2 mg/kg erysodine, respectively. Locomotor activity induced by a high dose of erysodine (10 mg/kg) was similar to those observed with saline injection in control rats, showing that the reduction in ethanol intake was not produced by hypolocomotor effect induced by erysodine. This is the first report showing that erysodine reduces ethanol intake in UChB rats in a dose-dependent manner. Our results highlight the role of nAChRs in the reward effects of ethanol and its modulation as a potentially effective pharmacological alternative for alcohol dependence treatment.es_ES
Patrocinadordc.description.sponsorship"Fondo Nacional de Desarrollo Cientifico y Tecnologico" (FONDECYT) 113-0012 115-0615 116-0398 CONICYTes_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceBehavioural Brain Researches_ES
Keywordsdc.subjectErysodinees_ES
Keywordsdc.subjectAlcohol dependencees_ES
Keywordsdc.subjectEthanoles_ES
Keywordsdc.subjectUChB ratses_ES
Keywordsdc.subjectnAChRs antagonismes_ES
Keywordsdc.subjectVoluntary ethanol drinkinges_ES
Títulodc.titleErysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB ratses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorrgfes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile