Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats
Author
dc.contributor.author
Quiroz, Gabriel
Author
dc.contributor.author
Guerra-Díaz, Nicolás
Author
dc.contributor.author
Iturriaga-Vásquez, Patricio
Author
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Rivera Meza, Mario
Author
dc.contributor.author
Quintanilla González, María Elena
Author
dc.contributor.author
Sotomayor Zárate, Ramón
Admission date
dc.date.accessioned
2018-11-07T21:01:42Z
Available date
dc.date.available
2018-11-07T21:01:42Z
Publication date
dc.date.issued
2018-09
Cita de ítem
dc.identifier.citation
Behavioural Brain Research Volumen: 349 Páginas: 169-176
es_ES
Identifier
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10.1016/j.bbr.2018.04.038
Identifier
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https://repositorio.uchile.cl/handle/2250/152475
Abstract
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Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol dependence. In this work, we assess the effectiveness of four doses of erysodine (1.5, 2.0, 4.0 or 8.0 mg/kg/day, i.p.), a competitive antagonist of nAChRs, on voluntary ethanol consumption behavior in alcohol-preferring UChB rats, administered during three consecutive days. Results show that erysodine administration produces a dose-dependent reduction in ethanol consumption respect to saline injection (control group). The highest doses of erysodine (4 and 8 mg/kg) reduce (45 and 66%, respectively) the ethanol intake during treatment period and first day of post-treatment compared to control group. While, the lowest doses of erysodine (1.5 and 2 mg/kg) only reduce ethanol intake during one day of treatment period. These effective reductions in ethanol intake were 23 and 29% for 1.5 and 2 mg/kg erysodine, respectively. Locomotor activity induced by a high dose of erysodine (10 mg/kg) was similar to those observed with saline injection in control rats, showing that the reduction in ethanol intake was not produced by hypolocomotor effect induced by erysodine. This is the first report showing that erysodine reduces ethanol intake in UChB rats in a dose-dependent manner. Our results highlight the role of nAChRs in the reward effects of ethanol and its modulation as a potentially effective pharmacological alternative for alcohol dependence treatment.
es_ES
Patrocinador
dc.description.sponsorship
"Fondo Nacional de Desarrollo Cientifico y Tecnologico" (FONDECYT)
113-0012
115-0615
116-0398
CONICYT