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Coumarins of haplopappus multifolius and derivative as inhibitors of lox: Evaluation in-vitro and docking studies

Authordc.contributor.authorTorres, Rene 
Authordc.contributor.authorMascayano, Carolina 
Authordc.contributor.authorNúñez, Carolina 
Authordc.contributor.authorModak, Brenda 
Authordc.contributor.authorFaini, Francesca 
Admission datedc.date.accessioned2018-12-20T14:14:02Z
Available datedc.date.available2018-12-20T14:14:02Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationJournal of the Chilean Chemical Society, Volumen 58, Issue 4, 2018, Pages 2027-2030
Identifierdc.identifier.issn07179707
Identifierdc.identifier.issn07179324
Identifierdc.identifier.other10.4067/S0717-97072013000400027
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/155077
Abstractdc.description.abstractSeveral natural compounds containing a coumarin moiety have been reported. They have multiple biological activities, e. g. , as scavengers of reactive oxygen species (ROS) and to reduce the inflammatory processes by inhibition of enzymes like COX or LOX. A study was made of the inhibitory capacity of seven natural coumarins and one derivative of esculetin, against soybean 15-lipoxygenase (15-sLOX). The studied coumarins showed interesting degrees of inhibition compared to quercetin, a known LOX inhibitor. Docking studies of some compounds into the binding site of 15-sLOX and 5-hLOX were also made.
Lenguagedc.language.isoen
Publisherdc.publisherSociedad Chilena de Quimica
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of the Chilean Chemical Society
Keywordsdc.subjectCoumarin inhibitors of LOX
Keywordsdc.subjectDocking.
Keywordsdc.subjectHuman lipoxygenase
Keywordsdc.subjectPercent inhibition values
Keywordsdc.subjectSoybean lipoxygenase
Títulodc.titleCoumarins of haplopappus multifolius and derivative as inhibitors of lox: Evaluation in-vitro and docking studies
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile