Gastroprotective activity of Parastrephia quadrangularis (Meyen), cabrera from the atacama desert
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2018Metadata
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Ardiles, Alejandro
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Gastroprotective activity of Parastrephia quadrangularis (Meyen), cabrera from the atacama desert
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© 2018 MDPI AG. All rights reserved. Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich s
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URI: https://repositorio.uchile.cl/handle/2250/155793
DOI: 10.3390/molecules23092361
ISSN: 14203049
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Molecules, Volumen 23, Issue 9, 2018,
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