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Evaluation of the in vitro and in vivo performance of two sustained- release lithium carbonate matrix tablets. Effect of different diets on the bioavailability

Authordc.contributor.authorGai, 
Authordc.contributor.authorFerj, 
Authordc.contributor.authorGarcía, 
Authordc.contributor.authorSeitz, 
Authordc.contributor.authorThielemann, 
Authordc.contributor.authorAndonaegui, 
Admission datedc.date.accessioned2018-12-20T15:04:07Z
Available datedc.date.available2018-12-20T15:04:07Z
Publication datedc.date.issued1999
Cita de ítemdc.identifier.citationDrug Development and Industrial Pharmacy, Volumen 25, Issue 2, 2018, Pages 131-140
Identifierdc.identifier.issn03639045
Identifierdc.identifier.other10.1081/DDC-100102153
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157454
Abstractdc.description.abstractTwo sustained-release (SR) lithium carbonate (Li) matrix tablets, which use a hydrophilic (HP) matrix of hydroxypropylmethylcellulose (Methocel 4K MP) and a lipid (L) matrix of hydrogenated castor oil (Cutina HR) as sustaining agents, have been studied. In vitro performance through dissolution tests in different media was established. The L and HP formulations were affected by the composition of the dissolution media, and liberation was complete in 8 hr using a variable-pH medium that simulates the gastrointestinal (GI) pH. Liberation was better described by the diffussional model of the square root of time for the L matrix and by zero-order kinetics for the HP matrix. Absolute bioavailability (BA) and food-induced changes on BA of both formulations were studied. The in vivo study design was a 4 x 4 Latin square involving 12 subjects who received two tablets of a 300-mg dose of SR formulations while fasting or with a standarized normal, high-fat, or high-fat/high-protein meal. The resu
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceDrug Development and Industrial Pharmacy
Keywordsdc.subjectDrug Discovery
Keywordsdc.subjectOrganic Chemistry
Keywordsdc.subjectPharmacology
Keywordsdc.subjectMolecular Medicine
Títulodc.titleEvaluation of the in vitro and in vivo performance of two sustained- release lithium carbonate matrix tablets. Effect of different diets on the bioavailability
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile